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Experimental and Mechanistic Research
MANTRA is the collection of laboratories in the Department of Critical Care Medicine devoted to preclinical studies of the Mechanisms And Novel Therapies for Resuscitation and Acute Illness. Overall direction is provided by Mitchell P. Fink, MD, and the Principal Investigators include: Michael Pinsky, Juan-Carlos Puyana, John Kellum, and Russell L. Delude. The laboratories making up MANTRA carry out studies using techniques ranging from fundamental cell and molecular biology and biochemical pharmacology to physiological measurements in large animals, such as pigs and dogs.
John Kellum, M.D. serves as co-director of the Department’s MANTRA laboratories and director of the molecular core for the CRISMA laboratories. Dr. Kellum’s research interests span the whole range of critical care medicine, but center on critical care nephrology, sepsis and multi-organ failure. He lectures worldwide and has given more than 300 seminars and invited presentations related to his research.
Mantra Labs:
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