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The
CRISMA Laboratory (Clinical Research, Investigation, and Systems
Modeling of Acute illness)
The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) is directed by Derek C. Angus MD, MPH, and co-directed by Gilles Clermont MD, MSc. This large team of clinicians, mathematicians, and epidemiologists enjoys superb funding from the NIH and multiple industrial sponsors. Regarded by many around the world as the leading investigative team carrying out studies of the clinical epidemiology of critical illness, Dr. Angus and his colleagues are actively studying the genetics of human sepsis, a syndrome that affects about 750,000 Americans every year and carries a mortality rate of almost 30 percent. Dr. Angus and his team of scientists have published papers in leading journals such as JAMA, Lancet, Critical Care Medicine, and the American Journal of Respiratory and Critical Care Medicine. [More]
MANTRA (Mechanisms And Novel Therapies for Resuscitation and Acute illness)
MANTRA is the collection of laboratories in the Department of Critical Care Medicine devoted to preclinical studies of the Mechanisms And Novel Therapies for Resuscitation and Acute Illness. Overall direction is provided by Mitchell P. Fink, MD, and the Principal Investigators include: Michael Pinsky, Juan-Carlos Puyana, John Kellum, and Russell L. Delude. The laboratories making up MANTRA carry out studies using techniques ranging from fundamental cell and molecular biology and biochemical pharmacology to physiological measurements in large animals, such as pigs and dogs. [More]
Clinical Trials Program
The Clinical Trials Program of the Department of Critical Care Medicine provides resources, facilities, and professionally trained staff to clinical investigators from diverse specialties to conduct research in a professional and ethical manner. Our aim is to facilitate research that may improve patient outcomes and advance clinical practice in the treatment of diseases and conditions affecting the critically ill or injured patient, while minimizing potential risk to the research subject. [More]
Safar
Center for Resuscitation Research (SCRR)
Research in Pediatric Critical Care Medicine is carried out at the Safar Center for Resuscitation Research, under the direction of Patrick M. Kochanek, M.D. Investigators at the Safar Center enjoy excellent funding from the NIH and various agencies of the Department of Defense. Research at the Safar Center, named for its founder, Distinguished Service Professor Peter J. Safar, focuses on two main areas: traumatic brain injury (TBI) and “suspended animation” or emergency preservation and resuscitation (EPR) (the currently preferred terminology). EPR refers to the futuristic notion of temporarily suspending circulatory and respiratory function in profound hypothermia to permit safe transport of trauma victims and surgical repair of devastating injuries followed by rewarming during cardiopulmonary bypass (CPB) for return of spontaneous circulation (ROSC) without long-term sequelae. Drs. Kochanek, Clark, Tisherman and colleagues have published several papers in high impact journals such as the Journal of Biological Chemistry and the Journal of Cerebral Blood Flow and Metabolism. [More]
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