Department of Critical Care Medicine

Research | Current and Recently Completed Grants

Adult Division
Title	Funding Agency	Total Period	P.I.
Genetic and Inflammatory Markers of Sepsis (GenIMS)	National Institute of General Medical Science	04/01/2001- 03/31/2006	Derek Angus
Economic Analysis of Pulmonary Artery Catheter Use	NIH/Agency for Healthcare Research	09/30/2001- 08/30/2006	Derek Angus
Learning Patient-Specific Models from Clinical Data	National Institutes of Health	01/24/2005- 01/23/2008	Derek Angus
Long-Term Outcomes of NO for Ventilated Premature Babies	National Institutes of Health	12/15/2002- 11/30/2007	Derek Angus
Coagulation Markers & Mediators in Sepsis	Glaxo Smith Kline	11/26/2002- 11/25/2010	Derek Angus
ICOS PAFASE Trial	ICOS Inc.	06/01/2002- 05/31/2006	Derek Angus
Evaluation of Ventilated Premature Newborns	INO Therapeutics	07/01/2004- 06/30/2007	Derek Angus
Management of Anemia in Critical Care (MACC II)	Amgen	10/20/2004- 11/30/2005	Derek Angus
Anemia and Transfusion Practices in Hospitalized Community Acquired Pneumonia	Ortho Biotech, Inc.	05/16/2003- 05/16/2006	Derek Angus
Myocardial Ischemia and Vasospasm in Aneurysmal Subarachnoid Hemorrhage(SAH).	National Institutes of Health	04/04/2004- 03/31/2005	Michael Horowitz
Modeling Host Immunity to Agents of Biological Terrorism	National Institutes of Health	07/01/2002- 06/30/2006	Gilles Clermont
International Conference on Complexity in Acute Illness	National Institutes of Health	04/01/2004- 03/31/2006	Gilles Clermont
Molecular Biology of Hemorrhagic Shock (Trauma Center) Project V : Predictive Mathematical Model of Inflammation	National Institutes of Health	04/01/2004- 03/31/2006	Gilles Clermont
Validation of Criteria Identifying Candidates For Non-Heart Beating Organ Donors	Health and Service Administration	09/01/2003- 08/31/2004	Michael DeVita
Crisis Resource Management Team Simulation Course	Jewish Healthcare Foundation	08/01/2004- 07/31/2006	Michael DeVita
First International Conference on Medical Emergency Teams (METS)	Robert Wood Johnson Foundation	01/01/2005- 09/30/2005	Michael A DeVita
METS: Preventing Patient Crises: Protecting in Crisis	Agency for Healthcare Research and Quality (AHRQ)	04/01/2005- 03/31/2006	Michael A DeVita
Howard Hughes Med Institute Research Training Fellow/Med Students	Howard Hughes Medical Institute	07/01/2003- 07/30/2005	Joshua Englert
Intestinal Perfusion and Permeability in Sepsis	National Inst of Gen Med Science	04/01/1987- 06/30/2008	Mitchell Fink
Pathogenesis of Experimental Necrotizing Enterocolitis	National Institutes of Health	12/01/2001- 01/312005	Mitchell Fink
Pathogenesis and Treatment of Experimental Peritonitis	National Institutes of Health	04/01/2002- 01/31/2005	Mitchell Fink
Ethyl Pyruvate: A Novel Treatment for Sepsis	National Institute of General Medical Science	07/01/2003- 06/28/2008	Mitchell Fink
A small volume mitochondrial preservation cocktail to delay development of irreversibility in combat casualties with hemorrhagic shock.	Defense Advanced Research Project Agency	01/01/2005- 12/31/2007	Mitchell Fink
Small Animals Studies for DARPA Nanomagnetic Particle Research	Materials Modification, Inc./Defense Advanced Research Project Agency	02/01/2005- 01/31/2006	Mitchell Fink
Molecular Biology of Hemorrhagic Shock: Project II, Molecular Basis for Epithelial Barrier Dysfunction	National Institutes of Health	07/01/2004- 06/30/2009	Mitchell Fink
Dynamics of Peritoneal Dialysis Associated Peritonitis	National Institutes of Health	07/01/2003- 06/30/2006	John Hotchkiss
Blood Purification in Experimental Sepsis	RenalTech International, LLC	09/01/2001- 08/31/2004	John Kellum, Jr
Hemadsorption To Improve Donor Organ Recovery	Health and Service Administration	09/01/2003- 08/31/2006	John Kellum, Jr
Intensive vs. Conventional Renal Support in Acute Renal Failure	VA Connecticut Healthcare System	11/01/2003- 10/31/2007	John Kellum, Jr
Cytosorb Clinical Project Development	RenalTech International, LLC	01/01/2004- 12/31/2004	John Kellum, Jr
Xigris Evaluation In the United States	Eli Lilly & Co. Inc.	09/08/2003- 09/30/2004	John Kellum, Jr
A Hemadsorption Device for the Treatment of SIRS	Medasorb/NIH	09/14/2004- 09/13/2005	John Kellum, Jr
Systems Engineering of Pheresis Intervention for Sepsis	National Institutes of Health	09/08/2005- 08/31/2010	John Kellum, Jr
Linezolid vs. Vancomycin/Oxacillin/Dicloxacillin in treatment of catheter	Pfizer	09/11/2002- 03/31/2005	Peter Linden
Mechanical Ventilation and Delirium	National Institutes of Health	07/01/2005- 06/30/2006	Eric Milbrandt
MRI TSC for Delirium in Mechanical Ventilation - Pilot Imaging Grant	Magentic Resonance Research Center, Univ. of Pitsburgh Medical Center	07/01/2005- 12/31/2006	Eric B. Milbrandt
Hypertonic Resuscitation fluid modulation of neutrophil function	Laerdal Foundation	07/01/2005- 06/30/2006	Holt Murray
Heart-Lung Interactions & Cardiovascular Insufficiency	National Institutes of Health	05/01/2002- 04/30/2007	Michael Pinsky
Evaluation of the Hemosonic 100	Arrow International	03/01/2002- 09/30/2004	Michael Pinsky
Experimental Therapeutics in Critical Illness	National Institutes of Health	09/01/2002- 08/31/2007	Michael Pinsky
Quantifying Left Ventricular Ejection Effectiveness	National Institutes of Health	08/15/2004- 07/31/2005	Michael R. Pinsky
Metabolic Inflammatory Systems in Irreversible Shock	National Institutes of Health	04/01/2004- 03/31/2008	Juan Puyana
Clinical Centers for the Clinical Network for the Treatment of Adult Respiratory Distress Syndrome	National Institutes of Health	10/31/2000- 10/31/2004	Juan Puyana
Schizophrenia Patient and Family Continuity of Care	National Institutes of Health	09/01/2001- 08/31/2007	Armando Rotondi
University of Pittsburgh Brain Injury Model System	National Institute on Disability & Rehabilitation Research	10/01/2002- 09/30/2007	Armando Rotondi
A Test of Two Online Interventions for Child Brain Injury	Cincinnati Children's Medical Center (National Institues of Health)	09/30/2003- 08/31/2009	Armando Rotondi
HMGB1 Alteration Tight Junction Structure and Function	National Institutes of Health	09/01/2004- 08/31/2009	Penny L. Sappington
A systems approach for improving region wide patient safety	National Institutes of Health	09/26/2001- 08/31/2004	Carl Sirio
Effecting Change in chronic Care: The Tipping Point	American Medical Association (AHRQ)	10/01/2002- 09/30/2006	Carl Sirio
Enhanced Patient Safety Intervention to Optimize Medication Education	Agency for Healthcare Research and Quality	07/01/2005- 06/30/2007	Carl Sirio
Consequences of surviving critical illness in childhood	National Institutes of Health	06/08/2004- 03/31/2009	R. Scott Watson
Micro-array Determinants of Outcome In Community Acquired Pneumonia	National Institutes of Health	04/01/2003- 03/31/2008	Kelly Wood

Pediatric Division
Title	Funding Agency	Total Period	P.I.
Improving the Diagnosis and Prognosis of Inflicted Head Trauma in Infants	Center For Disease Control	09/01/2003- 08/31/2005	Hulya Bayir
Therapeutic Hypothermia and Nitrosative Stress After Severe Traumatic Brain Injury	Laerdal Medical Foundation	01/01/2003- 06/30/2004	Hulya Bayir
Cardiolipin cytochrome C interaction in neuronal apoptosis after pediatric cardiopulmonary arrest.	American Heart Association	07/01/2005- 06/30/2006	Hulya Bayir
Mitochondrial Oxidtive Lipodomics in Cardiopulmonary Arrest	Laerdal Foundation	07/01/2005- 06/30/2007	Hulya Bayir
Laerdal Scientific Award	Laerdal Founation	01/01/2005- 12/31/2005	Sandra D.W. Buttram
Transfusion Medicine Hemostaisis Clinical Research Network	National Institutes of Health	09/30/2002- 08/31/2007	Joseph Carcillo
Novel Resuscitation From Lethal Hemorrhage Suspended Animation for Delayed Resuscitation	Army	09/15/2002- 09/14/2007	Joseph Carcillo
Metoclopramide prevents PICU Nosocomial Infection	National Institutes of Health	05/01/2005- 11/30/2010	Joseph A. Carcillo
PARS Activation After Traumatic Brain Injury (PP - Project #5)	National Institutes of Health	05/11/2000- 02/28/2005	Robert Clark
Divergent Pathways of Cell Death After Brain Injury	National Institutes of Health	02/01/2003- 01/31/2008	Robert Clark
PARS Activation After Traumatic Brain Injury (PP - Project #4)	National Institutes of Health	05/11/2000- 02/282005	Robert Clark
Gender-Specific Treatment of Pediatric Cardiac Arrest	National Institutes of Health	05/01/2005- 02/28/2010	Robert Clark
Adenosine and Traumatic Brain Injury	National Institutes of Health	08/01/1999- 07/31/2008	Patrick Kochanek
Gender Dependent Responses to Traumatic Hypothermia after Hyphxial Cardiac Arrest in a Pediatric Rat Model	Laerdal Foundation	01/01/2004- 12/31/2004	Ericka Fink
Creation implementation and evaluation of a novel pediatric critical care medicine education curriculum	Laerdal Foundation	07/01/2005- 12/31/2006	Melinda Fiedor
Identification of Biomarkers for inflicted traumatic brain injury using the human cerebrospinal fluid proteome	Centers for Disease Control	09/01/2004- 08/31/2006	Weiman Gao
Molecular Mechanisms of TBI: Bench to Bedside-Core C-Animal Modeling and Outcome	National Institutes of Health	05/11/2000- 02/28/2005	Patrick Kochanek
Protein Kinase B and C in Head Injury	National Institutes of Health	02/01/2005- 01/31/2006	Patrick Kochanek
Training in Pediatric Neurointensive Care and Resuscitation Research	NIH Nat Inst Child Health Human Dev	09/25/2000- 04/30/2005	Patrick Kochanek
Animal Modeling and Outcome – Core C	National Institutes of Health	05/11/2000- 02/282005	Patrick Kochanek
Molecular Mechanisms in TBI: Bench to Bedside Project 3 INOS and TBI	National Institutes of Health	05/11/2000- 02/28/2005	Patrick Kochanek
Improving the Diagnosis and Prognosis of Inflicted Head Trauma in Infants	Center For Disease Control	07/01/2003- 08/31/2006	Patrick Kochanek
Novel Resuscitation From Lethal Hemorrhage Suspended Animation for Delayed Resuscitability	United States Army	09/15/1998- 09/14/2005	Patrick Kochanek
Textbook on Resuscitation Medicine in the 20th Century	Laerdal Foundation	01/01/1997- 12/31/2007	Patrick Kochanek
Mechanisms of Chronic Dysfunction after Brain Trauma	National Institutes of Health	06/15/2005- 04/30/2009	Patrick Kochanek
The role of 20 Hete in the Pathogenesis of Stroke	National Institutes of Health	04/01/2005- 03/31/2006	Patrick Kochanek
Improving the Diagnosis and Prognosis of Inflicted Head Injury	Children’s Hospital of Pittsburgh/NIH	09/01/2005- 08/31/2006	Patrick Kochanek
Textbook on Resuscitation Medicine in the 20th Century	Laerdal Foundation	01/01/2004- 12/31/2005	Patrick Kochanek
The Third Annual Safar Symposium	United States Army	02/01/2005- 01/31/2006	Patrick Kochanek

Clinical Trials
Title	Funding Agency	Project Status	P.I.
A Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy and Safety of Epoetin Alfa in Critically Ill Subjects	Johnson & Johnson	open to enrollment	Juan Puyana
A Double-Blind, Placebo-Controlled, Parallel Group Phase 2 Dose-Ranging Study of Nebulized Amikacin Delivered Via the Pulmonary Drug Delivery System (PDDS) in Subjects With Ventilator-Associated Pneumonia Due to Gram-Negative Organisms.	Pfizer	open to enrollment	Scott Gunn
A Randomized, Double-Blind Study of GT267‑004 Versus Vancomycin, and GT267-004 Versus Metronidazole, in Patients with C. difficile-Associated Diarrhea	Genzyme	opening to enrollment soon	Juan Puyana
A Prospective, Randomized, Double-blind, Placebo Controlled, Dose Ranging, Multi-Center Study of the Safety and Efficacy of Three Days Continuous Intravenous Infusion of GR270773 in the Treatment of Suspected or Confirmed Gram-negative Severe Sepsis in Adults	Glaxo Smith Kline	open to enrollment	Scott Gunn
Cryptococcus neoformans Infection in Organ Transplant Recipients: Impact of Immunosuppressive Agent Resistance and Virulence Factors on Tissue Tropism and Outcome.	National Institutes of Health	open to enrollment	Nina Singh
CPCCRN Core Data Project (CCDP): Characterizing Patient Populations in the Collaborative Pediatric Critical Care Research Network (CPCCRN)	National Institutes of Health	Open to enrollment	Joseph Carcillo
Mechanical Ventilation and Delerium	National Institutes of Health	open to enrollment soon	Eric Milbrandt
An Observational Study Assessing the Use of Xigris® [Drotrecogin alfa (activated)] in Adult Patients with Severe Sepsis	Eli Lily and Co.	closed to enrollment	John A. Kellum
Investigation of the Efficacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis	Eli & Lilly	closed to enrollment worldwide due to low enrollment	Joseph A. Carcillo
A Double-Blind, Placebo-Controlled Study of E5564, A Lipid A Antagonist, Administered by Twice Daily Intravenous Infusions in Patients with Severe Sepsis	EISAI	closed to enrollment	John Kellum
Protocol PCT-7: Study of Procalcitonin in ICU Patients With Presumed or Confirmed Pneumonia and Requiring Mechanical Ventilation Using the LUMItest®PCT	Brahams	closed to enrollment	Ramesh Venkataraman
Multi-Center Clinical Trial of the BARD® Silver-Coated Entotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP)	BARD	closed to enrollment	Kelly Wood
A Multicenter, Double-Blind, Randomized, Comparison Study of the Efficacy and Safety of Tigecycline to Imipenem/Cilastatin to Treat Complicated Intra-Abdominal Infections in Hospitalized Subjects	Wyeth	closed to enrollment	Louis H. Alarcon
Donors After Cardiac Death: Validating Identification Criteria	HRSA	closed to enrollment	Michael DeVita
Systematic Collection of Data Regarding Combination Therapy When Used for the Treatment of Invasive Aspergillosis in Solid Organ Transplant Recipients	None	closed to enrollment	Nina Singh

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