NRSA Trainees on current funding cycle

David Nunley, MD
Michael Dishart, MD 1July 1997- 30 June 1999
Scott Gunn, MD 1 July 1999 - present (30 June 2001 current contract)
Jonathan Lebowitz October 1, 2000 - June 30, 2001
Steven Weisborg, MD July 30, 2001-June 2003
David Haung, MD July 2002-June 2004
Mingchen Song, MD, PhD July 2002-June 2005

1. Trainee: David Nunley, MD 1 July 1997- 30 June 1999
Principal Trainer: Theresa Whiteside, PhD
Trainer group: Adriana Zeevi, PhD
Michael R. Pinsky, MD
Vlad Kagen, PhD
Edwin Jackson, PhD

Year 1 activities:

1. Rotated through four laboratories (Whiteside, Kagen, Jackson, Zeevi) learning their basic techniques and cellular-molecular applications
2. Learned molecular techniques of PCR, Western blot, Northern Blot, isoelectric focusing, fluorescent cell sorting (Theresa Whiteside)
3. Initiated the study of the effect of GM-CSF on circulating immnocyte function in human sepsis (Peter Linden, Alan Rosenbloom, Theresa Whiteside, Michael Pinsky)
4. Initiated the study of the effect of continuous veno-venous hemofiltration with dialysis (CVVH-D) on circulating inflammatory mediators and immmunocyte function in human sepsis (John Kellum, Nick Johnson, Michael Pinsky, Theresa Whiteside)
5. Took postgraduate courses on statistical analysis and laboratory techniques from Graduate School of Cell Biology

Year 2 activities:

• Coursework "Advanced cardiopulmonary physiology" (Michael Pinsky)
• Research: "Mechanisms of cell-cell interaction in lung rejection (Andriana Zeevi, Michael Pinsky)

Publications:

1. Kellum JA, Vergato LA, Dishart MK, Nunley DR, Pinsky MR. Effect of hemofiltration filter adsorption on circulating IL-6 levels in septic rats. Am J Resp Crit Care Med. 159(3):A613, 1999 [abstract].
2. Nunley D, Zeevi A, Grgurich W, Bauldoff G, Iacono A, Hinton K, Pinsky MR. Expression of TGF-b in bronchoalveolar lavage fluid of cyctic fibrosis lung transplant recipients. Am J Repir Crit Care Med 161 (3):A368, 2000 [abstract].

Present position: Assistant Professor of Medicine and Pediatrics, Emory University Medical Center, Co-Director of the Adult and Pediatric Lung Transplantation Program.

2. Trainee: Michael Dishart, MD 1July 1997- 30 June 1999
Principal Trainer: Michael R. Pinsky, MD
Trainer group: John Gorcsan, III, MD
Bruce Pitt, PhD
Charles Buffington, MD

Year 1 activities:

1. Complete year-long clinical CCM fellowship
2. Learn echocardiographic techniques (transthoracic and transesophageal) (John Gorcsan)
3. Study conductance catheter volume artifact (Mark Feldman)
4. Study ventriculo-arterial coupling during anesthesia using echocardiographic imaging techniques (Michael Pinsky, Charles Bufifngton)

Year 2 activities:

• Coursework "Advanced cardiopulmonary physiology" (Michael Pinsky)
• Research: Myocardial energetics in animals and man (Michael Pinsky, John Gorcsan), and Ventriculo-arterial coupling during anesthesia (Michael Pinsky)

Publications:

1. Parker BM, Dishart MK, Pinsky MR, Kang Y. Is there occult tissue ischemia in chronic end-stage liver disease? Liver Transpl Surg 5(3):211-8, 1999.
2. Gorcsan JG, Dishart M, Mandarino WA, Feldman AM, Vergato L, Pinsky MR. Prevention of sepsis-induced depression of myocardial contractility by toborinone in anesthetized pigs. (submitted).
3. Parker BM, Dishart MK, Pinsky MR, Kang Y, De Wolf AM. Indirect Calorimetry and Core Body Temperature Measurement: Can They Predict Postoperative Outcome in Patients Undergoing Liver Transplantation? (submitted)
4. Dishart M, DeWolf A, Gasior T, Kang Y, Pinsky MR. Right Ventricular Function During Orthotopic Liver Transplantation. Anesthesiology 79(3A):A324, 1993 [abstract].
5. Gorcsan JG, Dishart M, Mandarino WA, Feldman A, Pinsky MR. Torborine Attenuates Myocardial Depression in Sepsis. Circulation 1997;96:I-714 [abstract].
6. Dishart M, Gorcsan III J, Mandarino WA, Pinsky MR. Left Ventricular (LV) Contractility is minimally Depressed in Early Porcine Endotoxic Shock. Am J Resp Crit Care Med. 159(3):A246, 1999 [abstract].
7. Kellum JA, Vergato LA, Dishart MK, Nunley DR, Pinsky MR. Effect of hemofiltration filter adsorption on circulating IL-6 levels in septic rats. Am J Resp Crit Care Med. 159(3):A613, 1999 [abstract].
8. Parker B, Dishart M, Pinsky M, Kang Y. Lower core body temperature predicts postoperative outcome in patients undergoing liver transplantation. Anesthesiology (in press)[abstract]

Present position: Clinical Assistant Professor, West Penn Hospital, Allegheny University Medical Center

3. Trainee: Scott Gunn, MD 1July 1999- 30 June 2001 (present contract termination date)
Principal Trainer: Michael R. Pinsky, MD
Trainer group: John Gorcsan, III, MD
Mark Roberts, MD
Derek Angus, MD

Year 1 activities:

1. Complete year-long clinical CCM fellowship
2. Learn echocardiographic techniques (transthoracic and transesophageal) (John Gorcsan)
3. Study conductance catheter volume measuring techniques (Michael Pinsky)

Year 2 activities:

• Coursework "Integrated experimental methods program" (includes separate training modules in Biostatistics 1, 2 and 3, Clinical Study Design 1 and 2, and Research Methods 1 and 2 (all modules are 8 weeks in duration)
• "Advanced cardiopulmonary physiology" (Michael Pinsky)
• Research: "Effect of left ventricular ejection asynchrony of contraction on myocardial energetics" (Michael Pinsky, John Gorcsan), and Ventriculo-arterial coupling during anesthesia (Michael Pinsky)

Publications: none

4. Trainee: Jonathan Lebowitz, MD 10 August 1999- 30 June 2001 (present contract termination date)
Principal Trainer: Nicholas Johnson, MD
Trainer group: Michael R. Pinsky, MD

Year 1 activities:

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