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Project Title:
MRI TSC for Delirium in Mechanical Ventilation - Pilot Imaging Grant
Funding Agency:
Magentic Resonance Research Center, Univ. of Pitsburgh Medical Center
Total Project Period:
Jul 1, 2005 - Dec 31, 2006
Principal Investigator:
Eric B. Milbrandt, MD
Project Summary:
The goal of this pilot-imaging project is to examine the role of occult diffuse brain injury in the underlying pathophysiology of ICU delirium. I will use high-resolution three-dimensional MRI to assess differences in brain tissue sodium concentration (TSC), a highly sensitive marker of tissue viability, to test the hypothesis that patients with delirium have occult ischemic brain injury as manifest by abnormal areas of increased TSC.
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