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Project Title:
Novel Resuscitation From Lethal Hemorrhage Suspended Animation for Delayed
Resuscitability
Funding Agency:
United States Army
Total Project Period:
Sep 15, 1998 - Sep 14, 2005
Principal Investigator:
Patrick Kochanek, MD
Co-Investigator(s):
Samuel Tisherman, Ala Nozari, Xianren Wu, S. William Stezoski, Larry Jenkins, Edwin Jackson, C. Edward Dixon, Joseph Carcillo, Franklin Bontempo, Edwin C. Klein, Ann Radovsky, Robert Garman, A. Hale, Miro Klain, Valerian Kagan, Sheryl Kelsey, John Gorcsan, D. Triuizi, R. Wagner, Andrew Peitzman, Paul Paris
Project Summary:
To maximize resuscitability in dogs from traumatic Exs CA of 60 min to CA of 120 min no-flow. Study II: To help increase feasibility of SA induction in the field by tests in dogs. Study III: To start exploring the limits of resuscitability during prolonged clinical death in rats in a systematic basic science plot project to identify chemical markers and histologic markers of cell death during CA without reperfusion, by focusing on mitochondria in brain and other vital organs under various temperatures.
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