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Project Title:
Improving the Diagnosis and Prognosis of Inflicted Head Trauma in Infants
Funding Agency:
Center For Disease Control
Total Project Period:
Jul 01, 2003 - Aug 31, 2006
Principal Investigator:
Patrick Kochanek, MD
Project Summary:
Inflicted Traumatic Brain Injury (iTBI) is a leading cause of serious TBI in infants and young children. Diagnosing iTBI is difficult, and misdiagnosis is common yet there are no established diagnostic adjuncts to help physicians properly identify iTBI. We have developed an international reputation for the study of biochemical markers in both non-inflicted (n)TBI and iTBI. In light of the exciting potential for this approach to lead ultimately to a clinical breakthrough, we propose a case-control study evaluating the utility of novel biochemical markers in the serum of infants at risk for iTBI as the centerpiece of a collaborative project by our group.
We will determine whether biochemical markers can serve as diagnostic adjuncts in a high-risk target population to identify potential infant victims of iTBI.
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