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Project Title:
Novel Resuscitation From Lethal Hemorrhage Suspended Animation for Delayed Resuscitation
Funding Agency:
Army
Total Project Period:
Sep 15, 2002 - Sep 14, 2007
Principal Investigator:
Joseph Carcillo, MD (Patrick Kochanek, MD – Principal Investigator)
Project Summary:
In year 5 (2002-03), we propose to conduct three studies simultaneously. Study I: To maximize resuscitability in dogs from traumatic Exs CA of 60 minutes (now partially successful) to CA of 120 minutes no-flow. Study II: To help increase feasibility of SA induction in the field by tests in dogs. 1) Reducing flush volume requirement by recirculating diluted venous blood via cooler without oxygenator or using ice slush solution. 2) Exploring flush and resuscitation via thoracotomy without CPB. 3) Testing new prototype devices developed by industry guided by us: novel catheters for rapid vessel access with and eithout thoracotomy; miniaturized portable cooling/pumping devices for induction of mild hypothermia (34 degree C) under spontaneous circulation and profound hypootheriic aortic cold flush (10 degrees C) under CA, portable CPB. Study III: To start exploring the limits of resuscitability during prolonged clinical death in rats in a systematic basic science pilot project to identify chemical markers (proteomics) and histologic markers of cell death (fluorojade) during CA without reperfusion by focusing on mitochondria in brain and other vital organs under various temperatures.
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