Titles:
Research Associate, Department of Critical Care Medicine

Lab Affiliation:  Clermont

Contact:
Email: zenkers@upmc.edu

Degrees:

Current Research Interest:

• use of mathematical modeling to further understanding of physiological processes and their influence on progression and outcome of disease, current focus: shock
• use of mathematical modeling and advanced data analysis techniques to help maximize the clinical value of the information obtained from non-invasive and invasive monitoring and diagnostic procedures in a critical care setting
• development of methods to combine deterministic models of physiological processes with stochastic data and models to better understand and eventually optimize diagnostic algorithms and underlying mechanisms

Publications:

• Zenker, S., Rubin, J., Clermont, G. From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses. PloS Computational Biology 2007 (in press)
• Kass, R., Rubin, J., Zenker, S. Invited comment on Ramsay, J.O., et al., "Parameter estimation for ordinary differential equations: a generalized smoothing approach", Journal of the Royal Statistical Society B 2007 (in press)
• Zenker , S., Polanco, P.M. , Kim, H.K., Torres, A., Vodovotz, Y., Clermont, G., Pinsky, M.R., Severyn, D.A., Puyana, J.C. Thresholded area over the curve (TAOC) of spectrometric tissue oxygen saturation (StO2) as an indicator of volume resuscitability in porcine hemorrhagic shock. Journal of Trauma-Injury Infection & Critical Care 2007 63(3) 573-580.
• Zenker, S., Clermont, G., Pinsky, M.R. Using mathematical models to improve the utility of quantitative ICU data. In: Vincent JL, editors. Yearbook of Intensive Care and Emergency Medicine 2007. Berlin Heidelberg New York: Springer. pp. 479-492.
• Zenker, S., Haverkamp, F., Klingmüller, D. Growth hormone deficiency in pituitary disease: relationship to depression, apathy and somatic complaints. European Journal of Endocrinology 2002 147(2) 165-171.
• Quade, G., Burde, B., Zenker, S., Goldschmidt, A. CancerNet online - ein Beitrag zur Verbesserung der onkologischen Versorgung. Zentralblatt für Gynäkologie 2000 122(12) 646-650.
• Quade, G., Zenker, S., Burde, B., Riedel, R.R., Goldschmidt, A. Differences in demographic data regarding physicians and patients in the US or abroad using a medically oriented Internet information service. Studies in Health Technology and Informatics 2000 77 668-672.
• Quade, G., Burde, B., Zenker, S., Nagel, W., Golschmidt, A. Recherchefunktionalität/ -algorithmen von Suchsystemen im Internet. In: Victor, N., Blettner, M., Edler, L., Haux, R., Knaup-Gregori, P., Pritsch, M., Wahrendorf, J, Windeler, J. Ziegler, S. (Eds.): Medical Informatics, Biostatistics and Epidemiology for Efficient Health Care and Medical Research. Urba & Vogel Medien und Medizin-Verl., Müchen (1999): 329-332

Presentations at Major Meetings:

• 10/2007, Invited lecturer: “Unbiased Representation of Population Variability in Mechanistic Ensemble Models”, 6th International Conference on Complexity in Acute Illness (ICCAI 2007), Long Beach, CA, USA
• 03/2007, Invited lecturer: “Mechanisms of Physiological Variability”, 7th World Congress on Trauma, Shock, Inflammation, and Sepsis (TSIS 2007), Munich, Germany
• 10/2006, Invited lecturer: “Models of the Cardiovascular System and its Control: Development to Clinical Application”, with Sanjeev Shroff, 5th International Conference on Complexity in Acute Illness (ICCAI 2006), Tyson's Corner, VA, USA
• 10/2006, Invited lecturer: “Physiological Bases of Variability”, ICCAI 2006

Teaching:

• Spring 2008 (planned): Graduate Level Topics Course „Parameter estimation for nonlinear ordinary differential equations“, University of Pittsburgh Dpt. of Mathematics
• Spring 2007: Instructor, “MATH0220: Calculus & Analytic Geometry 1“, University of Pittsburgh Dpt. of Mathematics
• Fall 2005, 2006, 2007: Lecturer in „MSCMP3790. A systems approach to inflammation“, University of Pittsburgh School of Medicine