Titles:
Department of Critical Care Medicine

Lab Affiliation:  SCRR

Contact:
Email: Wux@anes.upmc.edu

Degrees:

Major Honors/Awards:

• Nancy Caroline Fellow 2003

Research Grants:

Current Research Interest:

• Suspended Resuscitation
• Hemorrhagic Shock
• Emergency Hypothermia
  

Publications:

• Wu X, Stezoski J, Safar P, Nozari A, Tisherman S. After Spontaneous Hypothermia During Hemorrhagic Shock (HS), Continuing Mild Hypothermia (34C) Improves Early, But Not Late, Survival In Rats. J Trauma, 55(2): 308-16, 2003.
• Behringer W, Safar P, Wu X, Kentner R, Radovsky A, Kockanek PM, Dixon E, and Tisherman SA. Survival Without Brain Damage After Clinical Death of 60-120 Minutes in Dogs Using Suspended Animation by Profound Hypothermia. Crit Care Med, 31(5): 1523-31, 2003.
• Wu X, Stezoski J, Safar P, Bauer A, Tuerler A, Schwarz N, Kentner R, Behringer W, Kochanek P, Tisherman SA. Mild Hypothermia During Hemorrhagic Shock in Rats Improves Survival Without Significant Effects on Inflammatory Responses. Crit Care Med, 31(1):195-202, 2003.
• Wu X, Stezoski J, Safar P, Behringer W, Kentner R, Kochanek P, Tisherman SA. Systemc Hypothermia, But not Regional Gut Hypothermia, Improves Survival From Prolonged Hemorrhagic Shock in Rats. J Trauma, 53(4): 654-662, 2002.
• Behringer W, Safar P, Wu X, Nozari A, Abdullah A, Stezoski SW, Tisherman SA. Veno-venous Extracorporeal Blood Shunt Cooling to Induce Mild Hypothermia in Dog Experiments and Review of Cooling Methods. Resuscitation, 54: 89-98, 2002.
• Kentner R, Safar P, Behringer W, Wu X, Kagan VE, Tyurina YY, Henchir J, Ma L, Hsia CJC, and Tisherman SA. Early Antioxidant Therapy with Tempol during Hemorrhagic Shock Increases Survival in Rats. J Trauma, (in press) 2002.
• Studer W, Wu X, Siegemund M, and Seeberger M. Resuscitation from Cardiac Arrest with Epinephrine of Vassopressin: Effects on Intestinal Mucosal Tonometer PCO2 During the Post-Resuscitation Period in Rats. Resuscitation, 53(2): 201-207, 2002.
• Wu X, Kentner R, Stezoski J, Kochanek PM, Jackson EK, Carlos T, Carcillo J, Behringer W, Safar P and Tisherman SA. Intraperitoneal, but not Enteric, Adenosine Administration Improves Survival After Voulme-Controlled Hemorrhagic Shock in Rats. Critical Care Medicine, 29(9): 1767-1773,2001.
• Wu X, Prueckner S, Rollwagen F, Kentner R, Stezoski J, Kochanek PM, Behringer W, Pasculle WA, Safar P,and Tisherman SA. Gut Damage During Hemorrhagic Shock: Effects on Survival of Oral or Enteral IL-6. Shock, 16(6): 449-453, 2001.
• Behringer W, Safar P, Kentner R, Wu X, Kagan VE, Radovsky A, Clark RSB, Kochanek PM, Subramanian M, Tyurin VA, Tyurina YY, and Tisherman SA. Antioxidant Tempol Enhances Hypothermic Cerebral Preservation During Prolonged Cardia Arrest in Dogs. J Cereb Blood Flow Metab, 22(1):105-117, 2002.
• Kentner R, Rollwagen FM, Preuckner S,Behringer W, Wu X, Stezoski J, Safar P, and Tisherman SA. Effects of Mild Hypothermia on SUrvival and Serum Cytokines in Uncontrolled Hemorrhagic Shock in Rats. Shock (in press) 2002.
• Behringer W, Kentner R, Wu X, Tisherman SA, Radovsky A, Stezoski WS, Henchir J, Prueckner S, Safar P. Thiopental and Phenytoin by Aortic Arch Flush for Cerebral Preservation During Exsanguination Cardiac Arrest of 20 Minutes in Dogs. An Exploratory Study. Resuscitation, 49:83-97, 2001.
• Behringer W, Kentner R, Wu X, Tisherman SA, Radovsky, Stezoski WS, Henchir J Prueckner S, Jackson EK, Safar P. Fructose-1,6-Bisphosphate and MK-801 by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 minutes in dogs. An exploratory study. Resuscitation 50:205-216 2001
• Behringer W, Kentner R, Wu X, Tisherman SA, Radovsky, Stezoski WS, Henchir J Prueckner S, Jackson EK, Safar P. Fructose-1,6-Bisphosphate and MK-801 by aortic arch flush for cerebral preservation during exsanguination cardiac arrest of 20 minutes in dogs. An exploratory study. Resuscitation 50:205-216 2001
• Wu X, Siegemund M, Seeberger M, and Studer W. Systemic and mesenteric hemodynamics, metabolism, and intestinal tonometry in a rat model of supraceliac aortic cross-clamping and declamping. J Cardiothorac Vasc Anesth 13:707-714 1999
• Wu X, Studer W, Skarvan K, and Seeberger MD: High incidence of intravenous thrombi after short-term central venous catheterization of the internal jugular vein. J Clin Anesth 11: 482-485 1999
• Studer W and Wu X. Supraceliac aortic cross-clamping and declamping. Effects of dopexamine and dopamine on systemic and mesenteric hemodynamics, metabolism and intestinal tonometry in a rat model. Acta Anaesthesiol Scand 44: 241-248 2000
• Bolliger CT, Wyser C, Wu X, Hauser R, Studer W, Dalquen P, and Perruchoud AP: Evaluation of a new self-expandable silicone stent in an experimental tracheal stenosis. Chest 115: 496-501 1999
• Wu X, Zhang Z, Chen Y, and Wang X. Hemodynamic differences between different cardiopulmonary resuscitation techniques with intra-thoracic heart presser. (in Chinese with English abstract) J Clin Anesth (Nanjing, China) 13(2):65-68 1997
• Wu X, Chen Y, Zhang Z, and Wang X. Hemodynamic differences between different CPR techniques with intra-thoracic heart presser. (in Chinese) Chinese J Exp Surg (China) 13(3):186 1996
• . Wu X, Chen Y, Zhang Z, and Wang X. Intra-thoracic heart presser: a preliminary study. (in Chinese with English abstract) Acad J Sec Mil Med Univ (Shanghai, China) 16(2):138-142 1995
• Wu X, Chen Y, Zhang Z, and Wang X. Experimental study of intra-thoracic heart presser. (in English) J Med Coll PLA (Shanghai, China) 10(4):309-213 1995
• Wu. X, Li J, and Wang CC. Influences of pH and PCO2 of lidocaine on epidural anesthesia. A double blind study. (in Chinese with English abstract) J Clin Anesth (Nanjing, China) 11(3): 16-18 1995
• Wu X, Wang C, Li J, and Zhang Z. Hemodynamic response to continuous occlusion of aorta via intra-aortic balloon inflation in closed chest CPR. (in Chinese with English abstract) Acad J Sec Mil Med Univ (Shanghai, China) 14(2):151-56 1993
• Wu X and Li D. Effect of selective hypothermia on cortical ATPase during post-ischemic episode in rabbits. (in Chinese with English abstract) J Clin Anesth (Nanjing, China) 9(5):1-3 1993
• Wu X, Zhang ZH, and Zhang FJ. The use of fentanyl-bupivacaine in spinal anesthesia for renal transplantation.(in Chinese) J Clin Anesth (Nanjing, China) 8(5): 288 1992
• Wu X, Zhang FJ, and Zhang ZH. The use of high dose vitamin B12 epidurally-injected for post operative pain relief. (in Chinese) J Clin Anesth (Nanjing, China) 8(2): 112 1992
  

Presentations at Major Meetings:

• Feb. 20-25, 2004 Compared to Controlled Normothermia, Spontaneous Hypothermia (SH), with or without Neurotensin (NT), Improves Survival during Hemorrhagic Shock (HS) in Awake Rats. (Poster)
  Orlando, Florida. 33rd Critical Care Medicine
• June 7-11, 2003. Early or Delayed Mild Hypothermia (34°C) During Prolonged (6H) hemorrhagic Shock (HS) Improves Survival in Rats. (Poster)
  Phoenix, Arizona 26th Annual Conference of Shock
• Jan 28-Feb 2, 2003. During Prolonged (6 h) Uncontrolled Hemorrhagic Shock (UHS) with Hypotensive Fluid Resuscitation, Mean Arterial Pressure (MAP) must be Maintained Above 60-70 mmHg in Rats. (Poster)
  San Antonio, Texas, Society of Critical Care Medicine 32nd Annual Meeting
• Jan 26-29, 2002 1. Mild Hypothermia (34C) does not Increase Initial Bleeding from the Injured Liver after Hemorrhagic Shock (HS) in Pigs. (Poster)
  2. Resuscitation with Ringer’s Ethyl Pyruvate Solution (REPS) fails to Improve Long Term Survival Compared to Lactated Ringer’s (LR) Solution in a rat Model of Severe Volume-Controlled Hemorrhagic Shock (HS). (Poster)
  3. Inhibition of sodium/Hydrogen ion(Na+/H+) Exchange with Methyl Isobutyl Amiloride Impairs Tolerance to Hemorrhagic Shock in Rats. (Poster)
  San Diego, California, Society of Critical Care Medicine 31st Annual Meeting
• June 9-12, 2001 Delayed Mild Hypothermia prolongs Survival following Severe Hemorrhagic Shock (HS) in Rats.
  Marco Isloand, Florida, Twenty-Fourth Annual Conference of Shock
• Feb. 10-14, 2001 Mild Hypothermia during Hemorrhagic Shock (HS) Improves Survival without Significant Effects on Inflammatory Responses in Rats.
  San Francisco, California, Society of Critical Care Medicine 30TH International Educational and Scientific Symposium
• Oct. 14-18, 2000 1. Liver Damage during Prolonged Cardiac Arrest (CA) in Dogs. (Poster)
  2. Effects of Intraperitoneal (IP) and Enteric (EN) adenosine on Survival and Circulating cytokines after Prolonged Volume-controlled Hemorrhagic Shock (HS) in Rats. (Poster)
  San Francisco, California, American Society of Anesthesiologists annual meeting
• June 3-6, 2000 1. Intraperitoneal (IP) but not Enteric (EN) adenosine improves survival after prolonged volume-controlled hemorrhage shock (HS) in Rats. (Poster)
  2. Enteral or Oral IL-6 does not improve survival in rats during hemorrhagic shock. (Poster)
  Snowbird, Utah, Twenty-Third Annual Conference on Shock
• June 17-20, 1998. Hemodynamic, metabolic and intestinal tonometric effects induced by supracoeliac aortic cross-clamping in a rat model. (Oral presentation)
  Bergen, Norway, EACTA European Association of Cardiothoracic Anesthesiologists 13th annual meeting
• Oct. 18-22, 1997. Does catheterization of the internal jugular vein impair competence of the internal jugular valve? (Poster discussion)
  San Diego, California, ASA annual meeting
• June 25-28,1997. 1. Reperfusion after superacoeliac aortic cross-clamping in a rat model: Effects of fluid-loading on mesenteric oxygen transport, lactate flux and jejunal luminal PCO2. (Oral presentation)
  2. Reperfusion after supracoeliac aortic cross-clamping in a rat model: Effects of dopexamine on mesenteric oxygen transport, lactate flux and jejunal luminal PCO2. (Poster)
• Thessaloniki, Greece, EACTA European Association of Cardiothoracic Anesthesiologists 12th annual meeting
• May 3-5, 1997. Reperfusion after aortic cross-clamping in a rat model: Effects of dopexamine on mesenteric oxygen transport, lactate flux and jujunal luminal PCO2. (Poster)
  Lausanne, Switzerland, ESA annual meeting
• Nov. 18-25, 1994. Intra-thoracic heart presser in CPR and the anesthesiology in Shanghai. Guest Lecture. Dept. of Anesthesiology, Ullevaal University Hospital, Oslo, Norway