A. Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee.

Professional Experience:

1996-1999 Assistant Professor, Department of Anesthesiology, Mount Sinai Medical Center, NY, NY

1999-2003 Director, Cardiac Anesthesiology, Columbia-Presbyterian Medical Center, NY, NY

1999-2003 Florence Irving Assistant Professor of Anesthesiology, Columbia University, NY, NY

2003-present Director, Perioperative Clinical Research, Duke Clinical Research Institute, Duke University,

Durham, NC

2004-present Associate Professor with Tenure, Department of Anesthesiology, Duke University, Durham, NC

Selected Awards and Professional Activities:

2000-2003 Irving Scholar, Columbia University, NY, NY

2000-2003 Formulary & Therapeutics Subcommittee Member on Critical Care Therapeutics, New York Presbyterian Hospital

2000-2003 Publication Committee member, Society of Cardiovascular Anesthesiologists

2001-2003 New York State Society of Anesthesiologists, PGA Scientific Committee Member

2002 Association of University Anesthesiologists – elected full member

2002-2003 Subcommittee on Clinical Circulation member, Society of Cardiovascular Anesthesiologists

2003-present Scientific Committee member, Society of Cardiovascular Anesthesiologists

2004-present Institutional Review Board member, Duke University Health System

B. Peer-reviewed publications (in chronological order).

1. Santer M, Bennett-Guerrero E, Byahatti S, Czarnecki S, O’Connell D, Meyer M, Khoury J, Cheng X, Schwartz I, McLaughlin J. Base change at position 792 of Escherichia coli 16s rRNA affects assembly of 70s ribosomes. Proc Natl Acad Sci USA 1990; 87:3700-04.

2. Fujii AM, Aoyagi T, Flanagan MF, Takahashi T, Bennett-Guerrero E, Colan SD, Izumo S. Response of the hypertrophied left ventricle to tachycardia: importance of maturation. Am J Physiol 1993; 264:H983-93.

3. Bennett-Guerrero E, Young CC. Bronchospasm after adenosine administration. Anesth Analg 1994; 79: 386-8.

4. Bennett-Guerrero E, Jimenez JL, White WD, Baldwin BI, D'Amico EB, Schwinn DA. Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass graft surgery: a randomized, double-blind, placebo-controlled trial. JAMA 1996; 275:687-92.

5. Bennett-Guerrero E, Sorohan JG, Howell ST, Ayuso L, Cardigan RA, Newman MF, Mackie IJ, Reves JG, Mythen MG. Maintenance of therapeutic plasma aprotinin levels during prolonged cardiopulmonary bypass using a large dose regimen. Anesth Analg 1996; 83:1189-92.

6. Bennett-Guerrero E, Kramer D, Schwinn DA. Effect of acute and chronic reductions in thyroid hormone on perioperative outcome. Anesth Analg 1997; 85:30-6.

7. Bennett-Guerrero E, Ayuso L, Hamilton-Davies C, White WD, Barclay GR, Smith PK, King SA, Muhlbaier LH, Newman MF, Mythen MG. Relationship of preoperative serum anti-endotoxin-core antibody levels and adverse outcomes following cardiac surgery. JAMA 1997; 277:646-50.

8. Bennett-Guerrero E, Sorohan JG, Canada AT, Ayuso L, Newman MF, Reves JG, Mythen MG. e -aminocaproic acid plasma levels during cardiopulmonary bypass. Anesth Analg 1997; 85, 248-51.

9. Lubarsky DA, Glass PSA, Ginsberg B, et al for the Systematic Withdrawal of Perioperative Expenses (SWIPE) Group. The successful implantation of pharmaceutical practice guidelines: analysis of associated outcomes and cost savings. Anesthesiology 1997; 86:1145-60.

10. Bennett-Guerrero E, Sorohan JG, Gurevich ML, Kazanjian PE, Levy RR, Barbera AV, White WD, Slaughter TF, Sladen RN, Smith PK, Newman MF. Cost-effectiveness and efficacy of aprotinin as compared with e -aminocaproic acid in patients undergoing repeat cardiac operation: A randomized, blinded clinical trial. Anesthesiology 1997; 87:1373-80.

11. Booth JV, Landolfo KP, Chesnut LC, Bennett-Guerrero E, Gerhardt MA, Atwell DM, El-Moalem HE, Smith MS,Funk BL, Kuhn CM, Kwatra MM, Schwinn DA. Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Anesthesiology 1998; 89:602-11.

12. Gan TJ, Bennett-Guerrero E, Phillips-Bute, B, Wakeling H, Moskowitz DM, Olefulobi BY, Konstadt SN, Glass PSA, Bradford C, Machin S, Mythen MG and the Hextend ® study group.

Hextend â , a physiologically balanced plasma expander for large volume use in major surgery: a randomized Phase III clinical trial. Anesth Analg 1999; 88: 992-8.

13. Bennett-Guerrero E, Spillane WF, White WD, Muhlbaier LH, Gilbert WC, Gall SA, Smith PK, Newman MF. Epsilon-aminocaproic acid administration and stroke following coronary artery bypass graft surgery. Ann Thorac Surg1999; 7:1283-7.

14. Bennett-Guerrero E, Welsby I; Dunn TJ, Rosenthal Young L, Wahl TA, Diers TL, Phillips-Bute BG, Newman MF, Mythen MG. The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization after routine, moderate risk, elective surgery. Anesth Analg 1999; 89:514-9.

15. Bennett-Guerrero E, Panah MH, Bodian CA, Methikalam BJ, Alfarone JR, DePerio M, Mythen, MG. Automated detection of gastric luminal partial pressure of carbon dioxide during cardiovascular surgery using the Tonocap. Anesthesiology 2000; 92:38-45.

16. Bennett-Guerrero E, Barclay GR, Youssef ME, Hossain, Vela-Cantos F, Andres LA, Poxton IR. Exposure to Bacteroides fragilis endotoxin during cardiac surgery. Anesth Analg 2000;90:819-23.

17. Bennett-Guerrero E, McIntosh TJ, Barclay GR, Snyder DS, Gibbs RJ, Mythen MG, Poxton IR. Preparation and Preclinical Evaluation of a Novel Liposomal Complete-Core Lipopolysaccharide Vaccine. Infect Immun 2000 68:6202-6208.

18. Sekaran P, Ehrlich M, Hagl C, Leavitt ML, Jacobs R, McCullough JN, Bennett-Guerrero E. A comparison of complete blood replacement with varying hematocrit levels on neurological recovery in a porcine model of profound hypothermic (<5 degrees C) circulatory arrest. Anesth Analg. 2001; 92:329-34

19. Bennett-Guerrero E, Panah MH, Barclay GR, Bodian CA, Winfree WJ, Andres LA, Reich DL, Mythen MG. Decreased endotoxin immunity is associated with greater mortality and/or prolonged hospitalization after surgery. Anesthesiology 2001; 94:992-8.

20. Manspeizer HE, Imai M, Frumento RJ, Parides MK, Mets B, Bennett-Guerrero E. Arterial and venous thromboelastographic parameters differ during cardiac surgery. Anesth Analg 2001; 93:277-81.

21. Bennett-Guerrero E , Barclay GR, Weng PL, Bodian CA, Feierman DE, Vela-Cantos F, Mythen MG. Endotoxin neutralizing capacity of serum from cardiac surgical patients. J Cardiothorac Vasc Anes 2001; 15:451-4.

22. Bennett-Guerrero E , Feierman DE, Barclay GR, Parides MK, Sheiner PA, Mythen MG, Levine DM, Parker TS, Carroll SF, White ML, Winfree WJ. Preoperative and Intraoperative Predictors of Postoperative Morbidity, Poor Graft Function, and Early Rejection in 190 Patients Undergoing Liver Transplantation. Arch Surg 2001;136:1177-83.

23. Sukernik M, Mets B, Bennett-Guerrero E . Patent Foreamen Ovale and its Significance in the Perioperative Period. Anesth Analg 2001;93:1137-46.

24. Bennett-Guerrero E, Kahn RA, Moskowitz DM, Falcucci OA, Bodian CA. Comparison of Arterial Systolic Pressure Variation (SPV) With Other Clinical Parameters to Predict the Response to Fluid Challenges during Cardiac Surgery. Mount Sinai Medical Journal 2002; 69:96-100.

25. Wilkes NJ, Woolf RL, Powanda MC, Gan TJ, Machin SJ, Webb A, Mutch M,

Bennett-Guerrero E , Mythen M. Hydroxyethyl starch in balanced electrolyte solution (Hextend)--pharmacokinetic and pharmacodynamic profiles in healthy volunteers. Anesth Analg 2002;94:538-44.

26. Frumento RJ, Mongero L, Naka Y, Bennett-Guerrero E. Preserved Gastric Mucosal Perfusion in Cardiac Surgical Patients Administered Intravenous Perflubron Emulsion. Anesth Analg 2002; 94:809-14.

27. Erridge C, Stewart J, Bennett-Guerrero E, McIntosh TJ, Poxton IR. The biological activity of a liposomal complete core lipopolysaccharide vaccine. J Endotoxin Research 2002; 8:39:46.

28. Welsby I, Bennett-Guerrero E, Atwell D, White WD, Newman MF, Smith PK, Mythen MG. The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass. Anesth Analg 2002; 94:1072-8.

29. Chapman MV, Woolf RL, Bennett Guerrero E, Mythen MG. The effect of hypothermia on calculated values using saline and automated air tonometry. J Cardiothorac Vasc Anesth. 2002; 16:304-7.

30. Reich DL, Bennett-Guerrero E, Bodian CA, Hossain S, Winfree W, Krol M. Intraoperative tachycardia and hypertension are independently associated with adverse outcome in noncardiac surgery of long duration. Anesth Analg 2002; 95:273-7.

31. Martin G, Wakeling H, Bennett-Guerrero E, Mythen MG, EI-Moalem H, Gan TJ and the Hextend ® study group. A prospective, randomized comparison of thromboelastographic coagulation profile in patients receiving lactated Ringer's solution, 6% hetastarch in a balanced-saline vehicle, or 6% hetastarch in saline during major surgery. J Cardiothorac Vasc Anes 2002; 16:441-6.

32. Erridge C, Bennett-Guerrero E, Poxton IR. Structure and function of lipopolysaccharides. Microbes Infect 2002; 4:837-51.

33. Mets B, Frumento RJ, Bennett-Guerrero E, Naka Y. Validation of Continuous Thermodilution Cardiac Output in Patients Implanted with a Left Ventricular Assist Device. J Cardiothorac Vasc Anes 2002; 16:727-30.

34. O'Malley CM, Frumento RJ, Bennett-Guerrero E. Intravenous fluid therapy in renal transplant recipients: results of a US survey. Transplant Proc. 2002; 34:3142-5.

35. Frumento RJ, Hirsh AL, Parides MK, Bennett-Guerrero E. Differences in arterial and venous thromboelastography parameters: potential roles of shear stress and oxygen.

J Cardiothorac Vasc Anes 2002; 16:551-4.

36. Sukernik MR, Mets B, Kachulis B, Oz MC, Bennett-Guerrero E. The impact of newly diagnosed patent foramen ovale in patients undergoing off-pump coronary artery bypass grafting: case series of eleven patients. Anesth Analg 2002; 95:1142-6.

• Frumento RJ, O’Malley CMN, Bennett-Guerrero E. Stroke after cardiac surgery: A retrospective analysis of the effect of aprotinin dosing regimens. Ann Thor Surg 2003; 75:479-84.

38. Kavarana, MN, Frumento RJ, Hirsch AL, Oz MC; Daniel C. Lee DC, Bennett-Guerrero, E.

Gastric Hypercarbia And Adverse Outcome After Cardiac Surgery. Intensive Care Med 2003; 29: 742-8.

39. O’Malley C, Frumento RJ, Mets B, Naka Y, Bennett-Guerrero E. Abnormal Gastric Tonometric Variables And Vasoconstrictor Use After Left Ventricular Assist Device Insertion. Ann Thor Surg 2003; 75:1886-91.

40. Goswami S, Pamm JD, Bennett-Guerrero E. Unplanned Left Ventricular Assist Device Insertion After Elective “Low-Risk” Off-pump Coronary Artery Revascularization. J Cardiothorac Vasc Anes 2003; 17:499-501.

41. Bennett-Guerrero E, Hyam JA, Shaefi S, Prytherch DR, Sutton GL, Weaver PC, Michael G, Mythen MG, Grocott MP, Parides MK. Comparison Of P-POSSUM Risk-Adjusted Mortality Rates After Surgery Between Cohorts In The United States And The United Kingdom. Brit J Surg 2003;90:1593-1598.

42. O’Malley CMN, Frumento RJ, Mets B, Naka Y, Bennett-Guerrero E. Endotoxaemia During Left Ventricular Device Insertion: Relationship between Risk Factors and Outcome. Brit J Anesth 2004; 92:131-3.

43. Sukernik MR, Frumento R, Mets B, Jordan D, Bennett-Guerrero E, Cheung AT, Chaney MA. Intraoperative Diagnosis Of A Patent Foramen Ovale In A Patient Undergoing Coronary Artery Bypass Graft Surgery. J Cardiothorac Vasc Anes 2004; 18:101-6.

44. Down J, Barclay GR, Bennett-Guerrero E, Hamilton-Davies C, Stephens R, Grocott MP, Mythen MG. A Descriptive Study Of The Variation In Baseline Levels Of Anti-Endotoxin Core Antibodies Between US And UK Populations. J Endotoxin Research 2004; 10:195-6.

45. Hamilton MA, Chapman MV, Mutch M, Bennett-Guerrero E, Mythen MG. The Relationship between a Pentagastrin Stimulated Gastric Luminal Acid Production Test (Gastrotest) and Enteral Feeding Related Gastrointestinal Complications in Critically Ill Patients. Anesth Analg (In press)

46. Sukernik MR , Goswami S, Frumento RJ, Oz MC, Bennett-Guerrero E. National Survey Regarding The Management Of Intraoperatively Diagnosed Patent Foramen Ovale During Coronary Artery Bypass Graft Surgery . J Cardiothorac Vasc Anes (In press)

47. O’Malley CMN, Frumento RJ., Hardy MA, Benvenisty AI, Brentjens TE., Mercer JS, Bennett-Guerrero E . A Randomized, Blinded Comparison of Lactated Ringer’s Solution and 0.9% NaCl during Renal Transplantation. Anesth Analg (In press)

C. Research Support. List selected ongoing or completed (during the last three years) research projects (federal and non-federal support). Begin with the projects that are most relevant to the research proposed in this application. Briefly indicate the overall goals of the projects and responsibilities of principal investigator identified above.

Peer-Reviewed Grant Funding

1. NIH RO1 pending, submitted October 1, 2004 “Does Aprotinin Prevent Stroke (DAPS) Trial: Clinical”.

2. Irving Scholars Grant , Florence Irving Assistant Professorship – July1, 2000 to June 30, 2003

Principal Investigator for “Predictors of the Human Response to Lipopolysaccharide”.

Columbia University, NY.

3. Bayer Fellowship in Cardiovascular Anesthesia - July 1, 2000 to June 30, 2002

Principal Investigator for “Endogenous Kallikrein Inhibitors and Bleeding Following Cardiac Surgery”. Columbia University, NY.

Industry Sponsored Research

1. Synthetic Blood International, Inc. – 2004-present

Site Principal Investigator for Phase II Randomized Double-Blind Controlled Trial of Synthetic Oxygen Delivery Emulsion in Non-Cardiac Surgery.

2. Easai Pharmaceuticals – 2003-present

National Principal Investigator for Phase II Randomized Double-Blind Ascending Dose Trial in Cardiac Surgical Patients (Coordinating Center DCRI).

3. Alexion Pharmaceuticals - 2000-2001

Principal Investigator for “A phase II Randomized, Double-Blind, Placebo-Controlled Study of the Effect of h5G1.1-scFv on Total Mortality and Adverse Cardiovascular Ischemic Outcomes in Patients Undergoing Cardiopulmonary Bypass”. Columbia University, NY.

4. G.D. Searle & Co. - 2000-2001

Principal Investigator for “Clinical Protocol for Evaluation of the Safety and Efficacy of Parecoxib 40mg Q 12H Followed by Valdecoxib 40 mg Q 12H in Patients Who Have Coronary Artery Bypass Graft Via Median Sternotomy”. Columbia University, NY.

5. Alliance Pharmaceuticals, Inc. - 2000-2001