Titles:
Assistant Professor

Contact:
Email: yendes@upmc.edu

Degrees:

Positions and Employment:

• 2006-present - Assistant Professor of Critical Care Medicine, University of Pittsburgh School of Medicine
• 2005-2006 - Instructor, Department of Critical Care Medicine, University of Pittsburgh School of Medicine
• 2004-2005 - Chief Fellow Division of University of Tennessee Health Science Center, Pulmonary and Critical Care
• 1998-2002 - Research Associate, Methodist University Hospital

Major Honors/Awards:

• Young Investigator Award (American College of Chest Physicians) October 2003
• Cecile Lehman Mayer (American College of Chest Physicians) October 2000

Research Grants:

• Methodist Healthcare Foundation        1/1998-12/2000          
  Co-Investigator            $45,000
  Major goal of this project: The goal of this study was to ascertain causes of respiratory failure after CABG surgery and the role of genetic markers to predict prolonged mechanical ventilation after CABG surgery.

• Seed Grant- Critical Care Medicine      10/2006-9/2007
  Principal Investigator   $10,000
  Functional role of MIF polymorphisms in pneumonia and sepsis
  Major goal of this project:  To compare MIF protein and mRNA concentrations for the MIF -173 G/C polymorphism using ex vivo whole blood stimulation.

• Medimmune Inc                                  1/2007-12/2009
  Co-Principal Investigator (1.20 CY effort) $219,707  
  HMGB1 in sepsis
  Major goal of this project: To test efficacy of different monoclonal HMGB1 antibodies in models of severe sepsis and patients with sepsis. 

• K-23 - NIH                  7/2008-6/2013
  Principal Investigator (9.6 CY effort) $597,405
  Predicting risk of pneumonia in the general population
  Major goal of this project:  To develop a risk prediction tool based on a clinical exam and blood tests that could be done as part of a routine check-up to identify individuals at high risk for pneumonia.

• bioACCESS                 7/2008-6/2011
  Co-Principal Investigator (25% effort) pending
  Major goal of this project: i.) To conduct gene expression microarray to understand mechanisms underlying Eritoran (TLR4 antagonist) in treatment of severe sepsis; and, ii.) to conduct gene-association studies to identify genetic markers within the TLR4 signaling pathway associated with outcomes of severe sepsis and to conduct a pharmacogenetic study to assess if genetic determinants within the TLR4 pathway predict which individuals respond favorably or poorly to Eritoran.

Current Research Interest:

• Genetic and non-genetic factors affecting mechanical ventilation after bypass surgery
• Genetics of susceptibility to and outcomes after community acquired pneumonia
• Impact of critical care illness on long term outcomes in the elderly
  

Publications:

• Yende S, Angus DC, Ding J, Newman AB, Kellum JA, Li R, Ferrell RE, Zmuda J, Kritchevsky SB, Harris RB, Garcia M, Yaffe K, Wunderink RG.  4G/5G Plasminogen Activator Inhibitor-1 Polymorphisms and haplotypes are associated with pneumonia.  Am J Resp Crit Care Med 2007 Dec; 176(11):1129-1137.
• Yende S, D’Angelo G,  Kellum JA, Weissfeld LA, Fine J, Welch RD, Kong L, Carter M, Angus DC. Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med 2008 June, 177(11):1242-7.
• Yende S, Wunderink RG.  Effect of Clopidogrel on bleeding complications after coronary artery bypass surgery.  Crit Car Med 2001;29:2271-75
• Yende S, Wunderink RG.  Causes of prolonged mechanical ventilation after coronary artery bypass surgery.  Chest 2002;122(1):245-52.
• Yende S, Wunderink R.  Validity of scoring systems to predict risk of prolonged mechanical ventilation after coronary artery bypass surgery.  Chest 2002;122(1):239-244.
• Yende S, Quasney M, Tolley E, Qing Z, Wunderink R.  Association of TNF gene polymorphisms and risk of prolonged mechanical ventilation after coronary artery bypass surgery.  Crit Car Med 2003;31(1):133-140.
• Yende S, Quasney M, Tolley E, Wunderink R.  Clinical relevance of ACE gene polymorphisms to predict risk of mechanical ventilation after coronary artery bypass graft surgery.  Crit Car Med 2004;32(4): 922-7.
• Yende S, Tuomanen EI, Wunderink RG, Kanaya A, Newman AB, Harris T, de Rekeneire N, Krtichevsky SB.  Pre-infection Systemic Inflammatory Markers And Risk of Hospitalization Due to Pneumonia.  Am J Resp Crit Care Med 2005 Dec 1;172(11):1440-6. Epub 2005 Sep 15.
• Yende S, Waterer GW, Tolley EA, Newman AB, Bauer DC, Taafe DR, Jensen R, Crapo R, Rubin S, Nevitt MC, Simonsick EM, Satterfield S, Harris T, Kritchevsky SB.  Inflammatory Markers Are Associated With Ventilatory Limitation and Muscle Dysfunction in Obstructive Lung Disease in Well Functioning Elderly Subjects.  Thorax 2006 Jan;61(1):10-6. Epub 2005 Nov 11.
• Yende S, Angus DC, Sultanali I, Somes G, Newman AB, Bauer D, Kritchevsky SB.  Influence of Comorbid Conditions on Long-term Mortality after Pneumonia in Older People.  J Am Geriatr Soc 2007 Apr;55(4):518–525.
• Yende S, Lancaster D.  Hepatitis A: a potentially serious disease.  Ann Intern Med 1998;129(6):506-7.
• Yende S, Wunderink R.  An 87 year old man with hypotension and confusion after cystoscopy.  Chest 1999;115(5):1449-51.
• Yende S.  Effect of Clopidogrel on bleeding complications after CABG.  N Engl J Med 2002;346(3):207.
• Yende S.  Role of toll like receptor 4 (TLR4) mutations gram negative septic shock.  Arch Intern Med 2002;162(21):2496.
• SultanAli I, Zaman M, Yende S.  Sarcoidosis mimicking disseminated testicular cancer: case report.  South Med J 2005 Sep;98(9):935-6.

Presentations at Major Meetings:

• Inflammatory markers predict susceptibility to pneumonia. Yende S, Kritchevsky S, Wunderink RG, de Rekeneire N, Kanaya, A, Newmann A, Harris T, Tuomanen, E. Am J Resp Crit Car Med 2005;A246.*
• Mortality due to Community Acquired Pneumonia. SultanAli I, Kritchevsky S, Somes G, Newmann A, Bauer D, Garcia M, Harris T, Yende S. Am J Resp Crit Car Med 2005;A173.
• The Influence of Genetics on Mortality from Pneumonia.
  September 2005, European Respiratory Society 15th Annual Congress, Copenhagen, Denmark.
• Epidemiology and risk assessment scoring systems for severe CAP.
  October 2006, CHEST 2006: 72nd Annual International Scientific Assembly of the American College of Chest Physicians, Salt Lake, UT.
• Sepsis Pathophysiology and Epidemiology; Severe Sepsis Guidelines; and Sepsis Tutorial.
  September 2005, Society of Critical Care Medicine Board Review Course, Chicago, IL.
  

05-Apr-2007 dmk