Titles:
Associate Professor of Surgery with tenure and Associate Professor of CCM (second appointment)

Contact:
Email: tishermansa@ccm.upmc.edu

Degrees:

Positions and Honors:
1994-1999 University of Pittsburgh, Assistant Professor of Surgery
1994-1999 University of Pittsburgh, Assistant Professor of Anesthesiology/CCM (secondary appointment)
1999-2002 University of Pittsburgh, Associate Professor of Anesthesiology/CCM (secondary appointment)
1999-present University of Pittsburgh, Associate Professor of Surgery
2002-present University of Pittsburgh, Associate Professor of Critical Care Medicine

1999 University of Pittsburgh School of Medicine Class of 2000 – Excellence in Education Award
2000 Society of Critical Care Medicine, Shubin-Weil Award for Excellence in the Teaching and Ethical Practice of Critical Care Medicine

Research Support:

• “LY333328 versus Vancomycin in Skin/Skin-structure Infections”, Eli Lilly, University of Pittsburgh Principle Investigator, 1999-2000. Goal was to compare a new antibiotic (LY333328 to vancomycin in terms of efficacy for complicated skin infections
• “Prophylactic Antibiotics in the Management of Tube Thoracostomy for Traumatic Hemopneumothorax (PAMOTTTH study)”, Eastern Association for the Surgery of Trauma, 1999-present. Goal is to determine if prophylactic antibiotics are beneficial for patients who require chest tubes for trauma.
• “Novel Resuscitation from Lethal Hemorrhagic Shock”, Office of Naval Research, 2000-present. Goal is to develop novel resuscitation strategies to improve outcome from prolonged hemorrhagic shock.
• “Novel Resuscitation from Lethal Hemorrhage. Suspended Animation for Delayed Resuscitation”, US Army-Combat Casualty Care, 2000-present. Goal is to develop a novel resuscitation strategy called suspended animation that can preserve the exsanguinated trauma victim until delayed resuscitation and surgery are possible.
• “A Prospective, Randomized, Double-Blind, Multicenter Trial Assessing the Safety and Efficacy of Sequential (Intravenous/Oral) BAY 12-8039 (Moxifloxacin) 400 Mg every 24 hours Compared to Intravenous Piperacillin/Tazobactam 3.375 Grams every 6 Hours Followed by Oral Amoxicillin/Clavulanic Acid Suspension 800 Mg every 12 Hours for the Treatment of Patients with Complicated Intra-abdominal Infections.”, Bayer, University of Pittsburgh Principle Investigator, 2000-present. Goal is compare a new quinolone with standard antibiotics for the treatment of patients with complicated intra-abdominal infections.

Current Research Interest:

• Development of strategies to improve long-term survival from prolonged uncontrolled hemorrhagic shock, with a particular interest in hypothermia.
• Development of hypothermic and pharmacologic strategies to enable “suspended animation” for protection- preservation of the exsanguinated organism for transport and delayed resuscitation.
• Advanced resuscitation techniques for victims of refractory cardiac arrest, including cardiopumonary bypass and open-chest cardiopulmonary resuscitation.
• Treatment of complicated intra-abdominal infections
• Antibiotic use for tube thoracostomy placed for traumatic hemo/pneumothorax
• Use of simulation to teach crisis management skills

Publications:

• Kentner R, Safar P, Behringer W, Wu X, Kagan VE, Tyurina YY, Henchir J, Ma L, Tisherman SA: Early antioxidant therapy with Tempol during hemorrhagic shock increases survival in rats. J Trauma 2002;53:968-977.
• Wu X, Stezoski J, Safar P, Behringer W, Kentner R, Kochanek PM, Tisherman SA: Systemic hypothermia, but not regional gut hypothermia, improves survival from prolonged hemorrhagic shock in rats. J. Trauma 2002;53:654-662.
• Kentner R, Rollwagen FM, Prueckner S, Behringer W, Wu X, Stezoski J, Safar P, Tisherman SA: Effects of mild hypothermia on survival and serum cytokines in uncontrolled hemorrhagic shock in rats. Shock 2002;17:521-526.
• Wu X, Kentner R, Stezoski J, Kochanek PM, Jackson EK, Carlos TM, Carcillo J, Behringer W, Safar P, Tisherman SA: Intraperitoneal, but not enteric, adenosine administration improves survival after volume-controlled hemorrhagic shock in rats. Crit Care Med 2001; 29:1767-1773.
• Prueckner S, Safar P, Kentner R, Stezoski J, Tisherman SA: Mild hypothermia increases survival from severe pressure controlled hemorrhagic shock in rats. J Trauma 2001;50:252-262.