Titles:
Research Assistant Professor

Contact:
Email: stezoskisw@upmc.edu

Administrative Title:

• Research Coordinator- R&D, Suspended Animation (SA), SCRR
• Research Assistant Professor/ Scientist, Safar Center for Resuscitation Research, Dept. of Anesthesiology / CCM (2004)
• Research Assistant Professor/ Scientist, Safar Center for Resuscitation Research, Dept. of Critical Care Medicine (2005)
  

Major Honors/Awards:
Two new disclosures have recently been filed with the United States Patent and Trademark Office

• Disclosure Title(s): “Methods of Inducing Suspended Animation Following Cardiopulmonary Arrest” Serial No. 60/692,722 June 22, 2005
• “Cold Energy Infusion for Induction of Suspended Animation” March 17, 2005
  

Research Grants:

Current Research Interest:

• DAMD17-01-2-0038 (Kochanek PI) 09/15/04 – 09/14/05
  Study I: To maximize resuscitability in dogs from traumatic Exs CA of 60 min to CA of 120 min no-flow.
  Study II: To help increase feasibility of SA induction in the field by tests in dogs.
  Study III: To start exploring the limits of resuscitability during prolonged clinical death in rats in a systematic basic science plot project to identify chemical markers and histologic markers of cell death during CA without reperfusion, by focusing on mitochondria in brain and other vital organs under various temperatures.
  Role: Co-Investigator

Completed Research Interest:

• DAMD 17-02-2-0038 (Kochanek PI) 10/01/03 - 9/30/04 (6th yr)
  “Novel Resuscitation from Lethal Hemorrhage; Suspended Animation For Delayed Resuscitation”
  DAMD 17-01-2-0038 Safar (PI) 9/15/02 - 9/14/03 (5th yr)
  “Novel Resuscitation from Lethal Hemorrhage; Suspended Animation For Delayed Resuscitation”
  ONR #N00014-01-1- 0378 3-01-01 - 6-30-03
  “Novel Resuscitation from Lethal Hemorrhage”
  The goals of these study were to continue extending the duration of cardiac arrest from 60 to 90 and finally 120 minutes and still have good neurological outcome scores (ND%) and overall performance categorization (OPC) via Suspended Animation (SA). These neurological outcome improvements were accomplished via modified flushing procedures and newly designed circulatory and hypothermia equipment.
  Role: Co-Investigator

Publications:

• Bleyaert AL, Nemoto EM, Stezoski SW, Alexander H, Safar P: Amelioration of
  postischemic encephalopathy by sodium thiopental after 16 minutes of global
  brain ischemia in monkeys. Physiologist 18:3, 145, August 1975.
• Safar P, Stezoski SW, Nemoto EM: Amelioration of brain damage after 12
  minutes cardiac arrest in dogs. Arch Neurol 33:91-96, 1976.
• Bar-Joseph G, Safar P, Stezoski SW, Alexander H: Survival after severe
  hemorrhagic shock in monkeys: CNS, pulmonary, hepatic and renal outcome.
  Anesthesiology 57:A97, 1982.
• Wolfson SK, Safar P, Reich H, Clark JM, Gur D, Stezoski SW, Cook EE, Krupper MA: Dynamic heterogeneity of cerebral hypoperfusion after prolonged cardiac arrest in dogs measured by the stable xenon/CT technique: A preliminary study. Resuscitation 23:1-20, 1992.
• Pomeranz S, Safar P, Radovsky A, Tisherman SA, Alexander H, Stezoski SW: The effect of resuscitative moderate hypothermia following epidural brain compression on cerebral damage in a canine outcome model. J Neurosurg 79 : 241-251, 1993
• Nozari A, Safar P, Wu X, Stezoski SW, Henchir J, Kochanek PM, Klain M, Radovsky A, Tisherman: Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 min in dogs. J Trauma 57:1266-1275, 2004
  

Presentations at Major Meetings:

• Wu X, Kochanek PM, Stezoski SW, Tisherman SA: Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. American Association for the Surgery of Trauma mtg. 2004. Abstract published in AAST website www.aast.org.
• Wu X, Drabek T, Tisherman SA, Henchir J, Stezoski SW, Cochran K, Garman R, Kochanek PM: Suspended animation with delayed resuscitation allows intact survival from cardiac arrest resulting from prolonged lethal hemorrhage in dogs. 81. 34th SCCM Critical Care Congress, Crit Care Med 32(12 Suppl): A21, 2004g
• Drabek T, Stezoski J, Wu X, Tisherman SA, Stezoski SW, Cochran K, Safar P, Jenkins L, Kochanek PM: Establishment of a rat model of suspended animation with delayed resuscitation: A preliminary report. 211. 34th SCCM Critical Care Congress, Crit Care Med 32(12 Suppl):A56, 2004.