Lecturer (‘Venia legendi’): University of Muenster, Germany
Priv.-Doz.
2005
Anesthesiology and Surgical Critical Care
Board Certifications:
Year
Anesthesiology
2004
Positions and Employment:
2007-present - Assistant Professor of Critical Care Medicine and Anesthesiology, University of Pittsburgh School of Medicine
2006-2007 - Visiting Assistant Professor of Critical Care Medicine, University of Pittsburgh School of Medicine
Major Honors/Awards:
Student Travel Award, Society for Cyobiology, 1995
Postdoctoral Fellowship, DFG (German Research Foundation), 1997
Anesthesiology Specialty Award, Society for Critical Care Medicine, 1999
Byk-Grant, Austrian Postgraduate Assembly, 2000
Research Support :
Ongoing K08 1K08GM081459-01 Singbartl K, PI 09/10/2007 - 07/31/2012 Principal Investigator
NIH
Bacterial Pneumonia and Neutrophil
Recruitment during Acute Renal Failure
Major goal of this project: Bacterial pneumonia is the most common infection in sepsis, which still represents a leading cause of mortality in the United States. The morbidity and mortality of sepsis in turn greatly depend on renal function.
Completed Research Singbartl K, PI 2003-2005 Principal Investigator
Else Kroener Fresenius Foundation
(German Research Foundation DFG)
The Duffy Antigen Receptor for Chemokines during Acute Renal Failure
Major goal of this project: To identify the role of DARC in neutrophil recruitment during acute renal failure.
Singbartl K, PI 2001-2003 Principal Investigator
Else Kroener Fresenius Foundation
(German Research Foundation DFG)
Impact and mechanisms of Leukocyte Recruitment during Acute Renal Failure
Major goal of this project: To identify the mechanisms of leukocyte recruitment in different models of acute renal failure.
Current Research Interest:
Acute renal failure and inflammation
Publications:
Gibney N, Cerda J, Davenport A, Ramirez J, Singbartl K, Leblanc M. Volume management by renal replacement therapy in acute kidney injury. Int J Artif Organs 2008; 31(2):145-55.
Zarbock A, Schmolke M, Bockhorn SG, Schartre M, Bushmann K, Ley K, Singbartl K. The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation. Crit Care Med 2007; 35(9):2156-63.
Lauer S, Frerise H, Fischer LG, Singbartl K, Aken HV, Lerch M, Sielenkämper AW. The role of thoracic epidural analgesia in receptor-dependent and receptor-independent pulmonary vasoconstriction in experimental pancreatitis. Anesth Analg 2007; 105(2):453-9.
Zarbock A, Schmolke M, Spieker T, Jurk K, Van Aken H, Singbartl K. Acute uremia but not renal inflammation attenuates aseptic acute lung injury: a critical role for uremic neutrophils. J Am Soc Nephrol 2006 Nov; 17(11):3124-31. Epub 2006 Oct 11.
Scharte M, Jurk K, Kehrel B, Zarbock A, Aken HV, Singbartl K. IL-4 enhances hypoxia induced HIF-1alpha protein levels in human transformed intestinal cells. FEBS Lett 2006 Nov 27; 580(27):6399-404. Epub 2006 Nov 3.
Zarbock A, Singbartl K, Ley K. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest 2006 Dec 12; 116(12):3211-3219.
Singbartl, K., große Bockhorn, S., Zarbock, A., Schmolke, M., Van Aken, H. (2005) T cells modulate neutrophil-dependent acute renal failure during endotoxemia - Critical role for CD28. J Am Soc Nephrol, 16, 720-8
Singbartl, K., Ley, K. (2004) Leukocyte recruitment and acute renal failure. J Mol Med 82,91-101
Singbartl, K., Innerhofer, P., Radvan, J., Westphalen, B., Fries, D., Stogbauer, R., Van Aken, H. (2003) Hemostasis and Hemodilution: A Quantitative Mathematical Guide for Clinical Practice. Anesth Analg 96, 929-35
Olson, T. S., Singbartl, K., Ley, K. (2002) L-selectin is required for fMLP- but not C5a-induced margination of neutrophils in pulmonary circulation. Am J Physiol Regul Integr Comp Physiol 282, R1245-R1252
Singbartl, K., Thatte, J., Smith, M. L., Wethmar, K., Day, K., Ley, K. (2001) A CD2-green fluorescence protein-transgenic mouse reveals very late antigen-4-dependent CD8+ lymphocyte rolling in inflamed venules. J Immunol 166, 7520-6
Singbartl, K., Forlow, S. B., Ley, K. (2001) Platelet, but not endothelial, P-selectin is critical for neutrophil-mediated acute postischemic renal failure. FASEB J 15, 2337-44
Lindner, J. R., Song, J., Xu, F., Klibanov, A. L., Singbartl, K., Ley, K., Kaul, S. (2000) Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation 102, 2745-50
Singbartl, K., Green, S. A., Ley, K. (2000) Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure. FASEB J 14, 48-54
Singbartl, K., Ley, K. (2000) Protection from ischemia-reperfusion induced severe acute renal failure by blocking E-selectin. Crit Care Med 28, 2507-14
Presentations at Major Meetings :
The Duffy antigen receptor for chemokines (DARC) – A link between inflammation and hemostasis? (Presenter and Senior Author)
April 2006, Experimental Biology, San Francisco, CA
P-Selectin-dependent platelet-neutrophil-interaction (PNI) plays a key role in the development of HCI-induced acute lung injury (ALI). (Co-author).
April 2006, Experimental Biology, San Francisco, CA
The Duffy Antigen Receptor for Chemokines (DARC) – Linking inflammation and hemostasis. (Presenter and Senior Author)
September 2006, 19th ESICM Congress, Barcelona, Spain
