Titles:
Professor, CCM
Program Director, NRSA Training Program

Contact:
Email: pinskymr@ccm.upmc.edu

Degrees:

Administrative Title:

• Co-Director MANTRA (Mechanisms and Novel Therapies for Resuscitation and Acute Illness) Laboratory

Major Honors/Awards:

• 1969,70,72 University Scholar, McGill University
• 1980-1982 National Research Service Award
• 1981-1985 Assistant Professor of Medicine & Anesthesiology, University of Pittsburgh
• 1983-1986 Veterans Administration Career Development Award
• 1985-1986 Assistant Professor of Anesthesiology & CCM and Medicine, University of Pittsburgh
• 1985-2001 Director of Research, Dept. of Anesthesiology & CCM, University of Pittsburgh
• 1986-present Fellow, College of Chest Physicians
• 1986-1991 Associate Professor of Anesthesiology & CCM, University of Pittsburgh
• 1989-present Fellow, College of Critical Care Medicine
• 1991-2001 Professor of Anesthesiology, CCM, & Medicine, University of Pittsburgh
• 2001-present Professor of Critical Care Medicine, University of Pittsburgh
• 2002-2007 Mid-career Clinical Investigator Award, NHLBI K24
• 2003 Docteur honoris causa, University of Paris (V) La Sorbonne
• 2004 Sodalem Honoris Causa, Bohemian Society of Anesthesiol., Resuscit. and Acute Care Med
  

Research Grants:

Current Research Interest:

• Heart-lung Interactions
• Hemodynamic Monitoring
• Left Ventricular Function
• Right Ventricular Function
• Blood Flow Distribution
• Molecular Mechanisms in Sepsis
• Management of Shock
• Medical Education
• Health Services Research (protocolized care)

Publications:

• Buda AJ, Pinsky MR, Ingles NB, Daughters, GR, Alderman EL. Effect of intrathoracic pressure on left ventricular performance. N Engl J Med 1979; 301:453-9.
• Pinsky MR, Smith PL, Bleecker ER, Bromberger-Barnea E. Effects of antihistamines and indomethacin on hyperosmolar-induced vasodilation. Am J Physiol 1982; 242:H450-5.
• Pinsky MR, Summer WR, Wise RA, Permutt S, Bromberger-Barnea B. Augmentation of cardiac function by elevation of intrathoracic pressure. J Appl Physiol 1983; 54:950-5.
• Pinsky MR. Determinants of pulmonary artery flow variation during respiration. J Appl Physiol 1984; 56:1237-45.
• Pinsky MR. Instantaneous venous return curves in an intact canine preparation. J Appl Physiol 1984; 56:765-71.
• Pinsky MR, Marquez, Martin D, Klain M. Ventricular assist by synchronous increases in ITP. Chest 1987; 91:709-15.
• Novak RA, Matuschak GM, Pinsky MR. Effect of frequency on regional Ppl. J Appl Physiol 1988; 65:1314-23.
• Bernardi L, Keller F, Sanders M, Reddy P, Griffith B, Meno F, Pinsky MR. Respiratory sinus arrthymia in the denervated human heart. J Appl Physiol 1989; 67:1447-55.
• Guimond JG, Pinsky MR, Matuschak GM. Effect of synchronous increase in intrathoracic pressure on cardiac performance during acute endotoxemia. J Appl Physiol 1990; 69:1502-8.
• Stein KL, Kramer DJ, Killian A, Pinsky MR. Hemodynamic effects of synchronous HFJV in mitral regurgitation. J Appl Physiol 69:2120-5, 1990
• Reuse C, Vincent JL, Pinsky MR. Measurements of RV volumes during fluid challenge. Chest 1990; 98:1450-4.
• Pinsky MR, Vincent JL, DeSmet JM. Estimating left ventricular filling pressure during positive end-expiratory pressure in humans. Am Rev Respir Dis 1991; 143:169-78.
• Pinsky MR, Vincent JL, DeSmet JM. Effect of PEEP on RV function in man. Am Rev Respir Dis 1992; 146:681-7.
• Chelluri L, Pinsky MR, Donahoe M, Grenvik A. Long-term outcome of critically ill elderly patients requiring intensive care. JAMA 1993; 269:3119-23.
• Gorcsan J, Romand JA, Mandarino WA, Deneault LG, Pinsky MR. Assessment of LV performance by on-line pressure-area relationships by echocardiographic automated border detection. J Am Coll Cardiol 1994; 23:242-52.
• Gorcsan J, Gasior TA, Mandarino WA, Deneault LG, Hattler B, Pinsky MR. Assessment of the immediate effects of cardiopulmonary bypass on LV performance by on-line pressure-area relations. Circulation 1994; 89:180-90.
• Gorcsan J, Denault AY, Gasior TA, Mandarino WA, Deneault LG, Hattler B, Pinsky MR. Rapid estimation of LV contractility from ESPVR by echocardiographic ABD and arterial pressure. Anesthesiology 1994; 81:553-62.
• Pinsky MR. Cardiovascular effects of ventilator support and withdrawal. Anesth Analg 1994; 79:567-76.
• Romand JA, Shi W, Pinsky MR. Cardiopulmonary effects of IPPV during ALI. Chest 1995; 108:1041-8.
• Pinsky MR, Gorcsan J, Gasior T, Mandarino WA, et al. Changes in electrocardiographic morphology reflect instantaneous changes in left ventricular output in cardiac surgery patients. Am J Cardiol 1995; 76:667-74.
• Gorcsan J, Denault AY, Mandarino WA, Pinsky MR. LV pressure-volume relations using transesophageal automated border detection: comparison with conductance catheter technique. Am Heart J 1996; 131:544-52.
• Pinsky MR. Mechanical ventilation and the cardiovascular system. Current Opinion in Critical Care 1996; 2:391-5.
• Pinsky MR, Genc F, Lee KH, Delgado E. Contamination of hospital compressed air with nitric oxide: unwitting replacement therapy? Chest 1997; 111:1759-63.
• Denault AY, Gorcsan J, Kancel MJ, Mandarino WA, Deneault LG, Pinsky MR. End-systolic relations using echocardiographic ABD and arterial pressure to assess left ventricular contractility. Am J Physiol 1997; 272:H138-47.
• Gorcsan J, Strum D, Mandarino WA, Gulati V, Pinsky MR. Quantitative assessment of regional LV contractility alternations by tissue Doppler echocardiography and pressure-volume relations. Circulation 1997; 95:2423-33.
• Dhainaut JF, Pinsky MR, Nouria, Slomka F. Right ventricular function in human sepsis. Chest 1997; 112:1043-9.
• Pinsky MR. The hemodynamic consequences of mechanical ventilation. Intensive Care Med 1997; 23:493-503.
• Mandarino WA, Pinsky MR, Gorcsan JG. Assessment of left ventricular contractile state by preload-adjusted maximal power using echocardiographic automated border detection. J Am Coll Cardiol 1998; 31: 861-8.
• Michard F, Chemla D, Richard C, Wysocki M, Pinsky MR, Lecarpentier Y, Teboul JL: Clinical use of respiratory changes in arterial pulse pressure to monitor the hemodynamic effects of PEEP. AJRCCM 1999; 159:935-939.
• Denault AY, Gasior TA, Gorcsan J, Mandarino WA, Deneault LG, Pinsky MR. Determinants of aortic pressure variation during positive-pressure ventilation in man. Chest 1999; 116:176-86.
• Jellinek H, Krafft P, Fitzgerald RD, Schwartz S, Pinsky MR. Right atrial pressure predicts hemodynamic response to apneic positive airway pressure. Crit Care Med 2000; 28:672-678.
• Pinsky MR, Rico P. Cardiac contractility is not depressed in early endotoxic shock. AJRCCM 2000; 161,1087-93.
• Pinsky MR, Roman A, Buurman W, Content J, Vincent JL. Effect of ibuprofen and diethylcarbamazine on the hemodynamic and inflammatory response to endotoxin in the dog. Eur Surg Res 2000; 32:74-86.
• Krenn CG, Krafft P, Schaefer B, Pokorny H, Pinsky MR, Steltzer H. Effects of PEEP on hemodynamics and indocyanine green kinetics in patients after orthotopic liver transplantation. Crit Care Med 2000; 28:1760-65.
• Michard F, Boussat S, Chemla D, Anguel N, Mercat A, Lecarpentier Y, Richard C, Pinsky MR, Teboul J-L. Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure. Am J Respir Crit Care Med 2000; 162:134-8.
• van den Berg P, Pinsky MR. Systems approach to heart-lung Interactions. Netherlands J Med 2000; 57:113-31.
  38. Teboul JL, Pinsky MR, Mercat A, Nadia A, Bernardin G, Achard J-M, Boulain T, Richard, C. Estimating cardiac filling pressure in mechanically ventilated patients with hyperinflation. Crit Care Med 2000; 28:3631-6.
• Gorcsan JC, Strum DP, Mandarino WA, Pinsky MR. Color-coded tissue Doppler assessment of the effects of acute ischemia on regional ventricular function: Comparison with sonomicrometry. J Am Soc Echocardiogr 2001; 14:335-42.
• Denault AY, Gorcsan J, Pinsky MR. Dynamic effects of positive-pressure ventilation on canine left ventricular pressure-volume relations. J Appl Physiol 2001; 91:298-308.
• Pinsky MR. Hemodynamic monitoring in the ICU. Contrib Nephrol 2001; 132:92-113.
• Van den Berg P, Jansen JRC, Pinsky MR. The effect of positive-pressure inspiration on venous return in volume loaded post-operative cardiac surgical patients. J Appl Physiol 2002; 92:1223-31.
• Strum DP, Pinsky MR. Does dobutamine improve ventricular function during esmolol-induced regional myocardial dyskinesis in dogs? Anesth Analg 2002; 95:19-25.
• Chelluri L, Mendelsohn AB, Belle SH, Rotondi AJ, Angus DA, Donahoe MP, Sirio CA, Schulz R, Pinsky MR. Hospital costs in patients receiving prolonged mechanical ventilation. Dose age have an impact? Crit Care Med 2003; 31:1746-51.
• Clermont G, Kalassian KG, Angus DC, Linde-Zwirble WT, Ramakrishnan N, Linden PK, Pinsky MR. Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling. Crit Care Med 2003; 31:2627-33.
• Chelluri L, Im KA, Belle SH, Schulz R, Rotondi AJ, Donahoe MP, Sirio CA, Mendelsohn AB, Pinsky MR. Long-term Mortality and Quality of Life after Prolonged Mechanical Ventilation. Crit Care Med 2004; 32:61-9.
• Miro A, Rogers P, Pinsky MR. Effect of inspiratory, expiratory, and continuous positive airway pressure on the inspiratory work of breathing during acute bronchospasm. Crit Care 2004; 8(2):R72-81. Epub 2004 Feb 09.
• Jacques DC, Pinsky MR, Severyn D, Gorcsan J III. Influence of preload and afterload on mitral annular diastolic velocity by tissue Doppler and associated effects on the inflow to annular ratio to predict filling pressure. Chest 2004; 126:1910-1918.
• Rosenbloom A, Linden P, Dorrance A, Penkosky N, Cohen-Melamed MH, Pinsky MR. Effect of GM-CSF on leukocyte functional molecules in patients with systemic inflammatory response with severe infection. Chest 2005; 127(6):2139-50.
• Pinsky MR, Vincent J-L. Let us use the pulmonary artery catheter correctly and only when we need it. Crit Care Med 2005; 33(5):1119-22.
• Dohi K, Suffoletto MS, Schwartzman D, Ganz L, Pinsky MR, Gorcsan J. Utility of echocardiographic radial strain imaging to quantify LV dyssynchrony and predict acute response to cardiac resynchronization therapy. Am J Cardiol 2005; 96(1):112-6.
• Dohi K, Pinsky MR, Kanzaki H, Severyn D, Gorcsan J. Effects of radial left ventricular dyssynchrony on cardiac performance using quantitative tissue Doppler radial strain imaging. J Am Soc Echocardiogr 2006; 19:475-482.
• Vincent JL, Fink MP, Marini JJ, Pinsky MR, Sibbald WJ, Singer M, Suter PM, Cook D, Pepe PE, Evans T. Intensive Care and Emergency Medicine: Progress over the past 25 years. Chest 2006; 129:1061-1067.
• Gunn S, Kim HK, Harrigan P, Pinsky MR. Ability of aortic pulse contour and esophageal pulsed Doppler measures to estimate changes in left ventricular output. Intensive Care Med 2006; 32(10):1537-1546.
• Strum DP, Pinsky MR. Modeling ischemia-induced dyssynchronous myocardial contraction. Anesthes & Analg 2006; 103:846-853.
• Pinsky MR. Hemodynamic monitoring over the past 10 years. Crit Care 2006; 10:117-119.
• Hadian M, Pinsky MR. Evidence-based review of the use of the pulmonary artery catheter: Impact, Data and Complications. Crit Care 2006; 10(Suppl 3):S11-18.
• Pinsky MR, Permutt S, Wang Y-YL, Wang W-K, Baker RD, Rothe C, Mitzner W. The classical Guyton view that mean systemic pressure, right atrial pressure, and venous resistance govern venous return is correct. J Appl Physiol. 2006; 101(5):1528-1530.
• Pinsky MR, Delgado E, Hete B. Effect of transtracheal gas insufflation of gas exchange efficiency in the dog. Anesthes & Analg 2006; 103(12):846-853.
• Pinsky MR, DeVita MA. Taking the next step in emergency medical management. ICU Management 2006; 4:12-15 (www.icu-management.org).
  

Presentations at Major Meetings:

• 3-07-02 Honor lecture, Partners in Respiratory Care Excellence (Respiratory Care), Salisbury University & Peninsula Regional Medical Center, “Quality of Life after ARDS.”
• 3-11-02 Convocation Address, Mini-MBA Course (Bioscientists), University of Pittsburgh Katz School of Business, “Taking a pig to market: from laboratory to joint venture.”
• 3-19-02 22nd International Symposium of Emergency and Intensive Care, Brussels, Belgium, “Is mitochondrial dysfunction a marker of’ immune dysfunction?,” “Use of heart-lung interactions to diagnose cardiovascular insufficiency,”“ Heart-lung interactions.”
• 3-27-02 Surgical Grand Rounds, Visiting Professor, Department of Surgery, Queens Hospital, University of Hawaii,: “Pathophysiology of Acute Illness and New Treatment Strategies,” Hawaiian Critical Care Society: “Cardiovascular insufficiency with initiation and withdrawal of mechanical ventilation,” Clinical Management Conference: “Mechanical Ventilation of the Patient with Acute Lung Injury”
• 4-07-02 11th Annual LHAS Current Controversies in Medical Ethics: Ethical issues in critical care. University of Pittsburgh School of Medicine, “2020: Genetic testing, costs and access to ICU care.”
• 4-17-02 Extra-renal purification of the critically ill patient, Hospital Saint Creu i Pau, Barcelona, Spain, “Pathophysiology in the body compartments clearance” and “Sepsis: Inflammatory dysequilibrium”
• 5-20-02 98th International Conference of the American Thoracic Society, Atlanta, GA, Mini-symposium co-chair entitled: Functional Hemodynamic Monitoring, “Static and Dynamic Variations in CVP Predict Right Ventricular Performance,” and “Ventriculo-Arterial Coupling: Completing the Circle.”
• 5-29-02 1st Joint Conference “Actual problems of blood purification, nephrology and hemapheresis,” Russian Scientific Society of Specialists in Extracorporeal Blood Purification in Intensive Care & The Russian Society of Dialysis, Moscow, Russia, “Functional hemodynamic monitoring.”, Pro- and anti-inflammatory aspects of severe sepsis” and “Regional Blood Flow in Critical Illness and Its Impact on Blood Purification Treatments.”
• 7-1-02 Workshop em Terapia Intensiva Einstein-Pittsburgh-Pro Cardiaca, Rio de Janerio, Brazil, “Dynamic effects of positive pressure ventilation on cardiac function,” “Functional Hemodynamic Monitoring: Applied physiology at the bedside,” and “Immunologic dysfunction in sepsis.”
• 7-5/6-02 International Symposium Einstein-Pittsburgh, Associação Brasileira “A Hebraica” – Sao Paulo/SP, Brazil, Program Directors: Elias Knobel, MD & Michael R. Pinsky, MD, Current Controversies in Critical Care: Sepsis and Multiple Organ Dysfunction, “Immune dysfunction and immune-modulation therapy in ‘severe sepsis,” “Dynamic effects of positive-pressure ventilation on cardiac function,” “Septic shock pathophysiology: heart and circulation,” “Impact of hepatic transplantation in critically ill patients,” and “Implications of arterial pressure variation in ventilated patients.”
• 9-3-02 Obstetrics-Gynecology Grand Rounds, Magee Womens Hospital, UPMC, Pittsburgh, PA, “Pathophysiology and treatment of severe sepsis.”
• 9-17/20-02 Annual Scientific Meeting of the Continuing Education Committee of Anaesthetists in New Zealand (CECANZ), Christchurch, New Zealand, “The right ventricle under stress,” “Use of heart-lung interactions at the bedside to diagnose and treat cardiovascular insufficiency,” and “Intra-operative goals of resuscitation.”
• 11-15-02 Honor lecture, 4th Annual Symposium on Acute Care: Sepsis, pain and immune modulation, University of Vienna, Baden, Austria, “An objective view of sepsis trials and present day treatment.”
• 11-21/23-02 11th International Course of Intensive Care, Peruvian Society of Intensive Medicine, Lima, Peru, “Pathophysiology and Management of Circulatory Shock,” “Hemodynamic monitoring: tools or toys?” “Arterial flow and the microcirculation,” “ Cardiovascular insufficiency with initiation and withdrawal of mechanical ventilation,” “Functional hemodynamic monitoring.”
• 12-10-02 Give and Take: Oxygen Delivery and Utilization in Critical Care, University College London, Windsor, Berkshire, United Kingdon, “How we can increase delivery.”
• 12-13-02 British Intensive Care Society, State of the Art Meeting, London, United Kingdom, “Functional Hemodynamic Monitoring.”
• 12-19-02 Anesthesiology Grand Rounds, “Functional Hemodynamic monitoring,” University of Pittsburgh, School of Mediicne.
• 3-19/22-03  23rd International Symposium of Emergency and Intensive Care, Brussels, Belgium, Jean-Louis Vincent, MD, PhD, “Quantifying left ventricular ejection effectiveness,” “Altered immune response,” “Cardio-respiratory interactions during mechanical ventilation,” “RV dysfunction,” “Relevance of preload assessment,” and “Central venous pressure.”
• 5-28-03  14th SMART Congress, Fiera Milana Congressi Center, Massimo Antonelli, Antonio Braschi, Georgio Conti, Luciano Gattinoni, Antonio Persenti, F. Raimondi (Organizing and Scientific Committee), Milan, Italy, “Functional Hemodynamic Monitoring,” “Hemodynamic management in the ICU: What are the targets?” and “Teaching and learning end-of-life care.”
• 6-25/26-03  2nd International Symposium on Intensive Care and Emergency Medicine for Latin America, São Paulo, Brazil, Elias Knobel & Jean-Louis Vincent, co-chairmen, “Functional hemodynamic monitoring,” “Use of CVP to predict cardiac output responses to interventions,” “Role of pressure and flow on determining organ perfusion and oxygen utilization,” “ Sepsis: a pro- and anti-inflammatory unbalance syndrome.”
• 11-16-03  36th Annual Scientific Meeting of the American Society of Nephrology, “Renal Week 2003” Mini-Symposium: Endothelial Cell Dysfunction as a Mechanism of Disease,” San Diego, CA, Bruce Molitoris, MD, “Impact of the inflammatory response on the expression of cell surface molecules.”
• 3-3/4-04  6th World Congress on Trauma, Shock, Inflammation and Sepsis & 5th International Congress on shock, Klinikum Grosshadern, Ludwig-Maximillians-University, Munich, Germany, Eugene Faist, MD, “Has survival improved from ARDS?” and “Cardiovascular dysfunction in severe sepsis.”
• 5-21-04   99th Annual Scientific Meeting, American Thoracic Society, Orlando, FL, Co-chairman, Postgraduate course: Update on Critical Care: Hemodynamic Monitoring and Management, “Regulation of Systemic Blood Flow and O2 Delivery” and “Performance-Based Hemodynamic Monitoring: Pre-Load and Arterial Tone.”
• 9-21-04  Obstetrics-Gynocology Grand Rounds Magee Womens Hospital, Dr. Crombleholme, “Goals of resuscitation in the high risk patient.”
• 11-06-04  American Heart Association, New Orleans, LA, Symposium on Mechanical ventilation: The good, the bad and the ugly, Taylor Thompson, MD, “Cardiovascular insufficiency with initiation and withdrawal of mechanical ventilation.”
• 1-18-05  34th Critical Care Congress, Society of Critical Care Medicine, Phoenix, AZ, Craig Coopersmith, MD, Program Chairman, Session Chairman: Hemodynamic monitoring landscape: Broader Horizons; “Functional hemodynamic monitoring: Physiologic relevance.”
• 3-07-05  Critical Care Medicine Grand Rounds, Università Cattolica, Department of Critical Care and Anesthesiology, Rome, Italy, Massimo Antonelli, MD, “Use of heart-lung interactions to diagnose cardiovascular insufficiency.”
• 5-24-05  100th ATS Annual Scientific meeting, San Diego, CA, “Static versus dynamic measures of cardiovascular insufficiency.”
  8-27/31-05  9th World Congress of the World Federation of Societies of Intensive Care Medicine (WFSICM), Buenos Aires, Argentina, Carlos Apezteguia, Chairman, Scientific Committee and Fernando Palizas, Chairman, Board of Directors. Member, International Advisory Committee. “Mechanism-specific view of anti-sepsis clinical trials,” “Functional hemodynamic monitoring,” “Regional blood flow distribution in critical illness,” “Identifying preload responsiveness.”
• 9-24/26-05  18th annual congress, European Society of Intensive Care Medicine, Amsterdam, Netherlands, Rui Moreno, MD, Program Chairman, “Left ventricular Starling curves,” “Patient-resuscitation interactions and tissue wellness,” “Is there a place for TPN in the ICU?,” “Fluid restriction in ARDS.”
  10-31-05  CHEST 2005, American College of Chest Physicians, Montreal, Quebec, “Cardiac function determined by ventilatory support,” “Functional hemodynamic monitoring.”
• 2-8/11-06   12th Indian Intensive Care Society meeting, Criticare Chennai, N. Ramakrishnan, Secretariat, Chennai (Madras), India. “Principals and applications of pressure monitoring using the PAC,” “Assessing fluid responsiveness,” “Patient resuscitation interactions and tissue wellness,” “Heart-Lung Interactions,” “PA Catheter losing its value as a monitoring tool?” and  “Intrinsic PEEP.”
• 5-24-06  Nephrology Update 2006, Cleveland Clinic, Cleveland, OH, Emilio Paganini and Marc Pohl, Co-directors, Ritz Carlton Hotel, Cleveland, OH “To Flood or Not to Flood: That IS the question.”
• 8-27/28-06  14th ASACCM meeting, Beijing, PAC, Du Bin, MD chairman, “Hemodynamic monitoring in sepsis,” “Cardiovascular insufficiency with initiation and withdrawal of mechanical ventilation,” “Intrinsic PEEP,” “Functional hemodynamic monitoring,” “Rational use of the pulmonary artery catheter.”
• 9-24/27-06  19th Annual congress European Society of Intensive Care Medicine, Barcelona, Spain, “What can we learn from hemodynamic monitoring regarding fluid responsiveness in shock?” and “How do I use hemodynamic monitoring to guide resuscitation?”
• 10-21/23-06  72nd Annual International Scientific Assembly: CHEST 2006, Salt Palace Convention Center, Salt Lake City, Utah. Pre-meeting Post-Graduate Course: Comprehensive Overview: Pulmonary Vascular Disease; “Cardiopulmonary Interactions.” Regular meeting, “Defining preload responsiveness in the critically ill patient.”
• 2-19-07  36th Critical Care Congress, Society of Critical Care Medicine, Orlando, FL, “Using arterial pulse contour analysis in hemodynamic monitoring.”
• 3-8/9-07  12th International Conference on Continuous Renal Replacement Therapies, Del Coronado Hotel, Del Coronado, Ravi Mehta, MD, Chairman, “Renal Effects of Critical Illness,” and “Targeted resuscitation: Strategies for success.”