Titles:
Research Scholar, Pediatric CCM

Contact:
Email: laixyc@ccm.upmc.edu

Degrees:

Major Honors/Awards:

1993 Society for Penn Medical Scholars
1996 Alpha Omega Alpha
2003 Society of Critical Care Educational Award
2003 Society of Critical Care Educational Award

Selected peer-reviewed publications (in chronological order):

1. Seidberg NA, Clark RSB, Zhang X, Lai Y, Chen M, Graham SH, Kochanek PM, Watkins SC, Marion DW: Alterations in inducible 72 kilodalton heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury. J Neurochem 84:514-521, 2003

2. Lai Y, Kochanek PM, Adelson PD, Janesko K, Ruppel RA, Clark RSB: Inducible 72 kD heat shock protein is increased after traumatic brain injury in infants and children. In press. J. Neurotrauma 21(3):229-237, 2004

3. Fink EL, Alexander H, Marco CD, Dixon CE, Kochanek PM, Jenkins LW, Lai Y, Donovan HA, Hickey RW, Clark RSB: An experimental model of pediatric asphyxial cardiopulmonary arrest in rats. Pediatr Crit Care Med 5(2): 139-144, 2004.

Abstracts:

1. Lai Y, Paollilo J, Ettedgui J, Park S. Myocardial ischemic episode following nebulized racemic epinephrine therapy. Presented at Ohio Doctors Interested in Congenital Heart, 1999

2. Lai Y, Kochanek PM, Adelson PD, Janesko K, Ruppel RA, Clark RSB: Inducible 72 kD heat shock protein is increased in cerebrospinal fluid after traumatic brain injury in infants and children. Crit Care Med 28:A39, 2001

3. Lai Y, Du L, Wong HR, Kochanek PM, Jenkins LW, Dunsmore K, Graham SH, Clark RSB. TAT-Hsp70 protects neurons from peroxynitrite and glutamate-induced cell death. Program No. 225.10. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002 CD-ROM

4. Lai Y, Kochanek PM, Shore PM, Janesko K, Bayir H, Clark RSB. Age-related increase in protein kinase B (Akt) after pediatric traumatic brain injury. Crit Care Med 30:A7, 2002

5. Lai Y, Du L, Kochanek PM, Clark RSB. Mitochondrial overexpression of heat shock protein 70 protects neurons from oxidative stress. Crit Care Med 30:A23, 2002

6. Lai Y, Du L, Zhang X, Kochanek PM, Jenkins LW, Graham SH, Clark RSB. Gender-dependent responses to staurosporine-induced apoptosis in rat primary cortical neurons. Program No. 636.17. 2003 Abstract Viewer/Itinerary Planner. Society for Neuroscience, 2003 CD-ROM

7. Fink EL, Alexander H, Marco CD, Kochanek PM, Jenkins LW, Lai Y, Hickey RW, Clark RSB. A novel experimental model of pediatric asphyxial cardiac arrest that produces prolonged functional deficits and neurodegeration. Pediatric Academic Societies’ Meeting, 2003

8. Du L, Zhang X, Lai Y, Kochanek PM, Jenkins LW, Graham SH, Clark RSB. Gender-dependent responses to excitotoxicity in rat primary cortical neurons. Program No. 747.17 2003 Abstract Viewer/Itinerary Planner. Society for Neuroscience, 2003 CD-ROM

9. Lai Y, Satchell MA, Wisniewski SR, Janesko K, Kochanek PM, Clark RSB. Increased cerebrospinal fluid cytochrome c after pediatric brain injury dependent upon mechanism of injury and gender. Crit Care Med 31:A12, 2003

10. Cousar JL, Lai Y, Kochanek PM, Janesko K, Shore PM, Clark RSB. Heme oxygenase-1 is increased in cerebrospinal fluid after pediatric traumatic brain injury. Crit Care Med 31:A11, 2003

11. Stange CJ, Lai Y, Wisniewski SR, Janesko K, Kochanek PM, Clark RSB. Mitochondrial heat shock protein 60 is elevated in the cerebrospinal fluid after pediatric traumatic brain injury. Crit Care Med 31:A12, 2003

12. Shore PM, Berger RP, Clark RSB, Adelson PD, Lai Y, Bayir H, Wisniewski SR, Thomas N, Varma S, Janesko K, Kochanek PM. Glasgow coma scale score does not correlate with cerebrospinal fluid markers of brain injury after severe traumatic brain injury in child abuse victims, infants or toddlers. Crit Care Med 31:A91, 2003

13. Bayir H, Adelson PD, Kagan VE, Brown DF, Shore PM, Lai Y, Clark RSB, Kochanek PM. The effect of therapeutic hypothermia on nitrosative stress after traumatic brain injury in infants and children. Crit Care Med 31:A92, 2003

14. Bayir H, Du L, Lai Y, Jenkins LW, Kochanek PM, Clark RSB. Gender-dependent differences in glutathione metabolism in neurons after nitrosative stress and in brain after hypoxia-ischemia. Pediatr Res 55(4):25A, 2004

15. Fink EL, Marco CD, Holly AD, Alexander H, Kline AE, Dixon CE, Bao L, Lai Y, Kochanek PM, Clark RSB. Gender-dependent differences in behavioral outcome and rate of neuronal cell death after asphyxial cardiac arrest in post-natal day 17 rats. Pediatr Res 55(4):25A, 2004