Department of Critical Care Medicine

John Kellum, MD

Titles:
Professor, Critical Care Medicine

Contact:
Email: kellumja@ccm.upmc.edu

Dr. Kellum’s research interests span various aspects of Critical Care Medicine, but center in critical care nephrology (including acid-base, and renal replacement therapy), sepsis and multi-organ failure (including blood purification), and clinical epidemiology. He has authored more than 200 publications and has won several awards for teaching. He lectures widely and has given more than 300 seminars and invited lectures related to his research. Dr. Kellum a founding member and past president of the Acute Dialysis Quality Initiative (www.ADQI.net). He is co-director of the MANTRA laboratories (Mechanisms And Novel Therapies for Resuscitation and Acute illness) and director of the molecular core for the CRISMA laboratory (Clinical Research Investigation and Systems Modeling of Acute illness) at the University of Pittsburgh.

Degrees:

POST GRADUATE EDUCATION INSTITUTION AND LOCATION	DEGREE	YEAR	FIELD
Medical College of Ohio at Toledo	MD	1988	Medicine
Residency:
University of Rochester, Strong Memorial Hosp & Affiliate Hospitals, Rochester, NY	Intern /Resident	1988-1992	Internal Medicine
Fellowship:
University of Pittsburgh Medical Center, Pittsburgh, PA	Fellow	1992-1994	Critical Care Medicine
Other:
Coursework toward MPH (biostatistics, epidemiology)		1993-1994
Board Certifications:			Year
ABIM – Internal Medicine			1991
ABIM – Critical Care Medicine			1996

Administrative Title:
Co-Director MANTRA (Mechanisms and Novel Therapies for Resuscitation and Acute Illness) Laboratory

Honors/Awards:

1998 Fellow, American College of Physicians
1999 MCCTP Faculty of the Year
1999 Fellow, American College of Critical Care Medicine (FCCM)
2002 Keynote Address: Intensive Care Society of Ireland,
Londonderry, Ireland
2002 Thomas Iberti Memorial lecturer, Rochester, NY
2004 Keynote Address: Second International Symposium on Critical Care Nephrology Melbourne, Australia
2005-2011 Member, American Board of Internal Medicine, CCM Exam Committee

Research Grants:

Title	Source of Support
Multi-Center Phase 3 Study of Activated Protein C (EVAAD) in Sepsis” PI: John Kellum (University of Pittsburgh Site PI) Co-Investigator: Carl Sirio, MD, Peter Linden, MD, R Cefola RPh, J Kerfonta RPh. 1998 –2000	Eli Lilly and Company
PMX 622 in severe SIRS. PI: Carl Sirio (University of Pittsburgh Site PI) Co-investigators: Peter Linden, John Kellum. 1998 – 2000	Novartis Pharmaceuticals
Mechanisms of Immunomodulation by hemofiltration in experimental sepsis. July 1, 1999 - June 30, 2000 PI: John A Kellum, MD	Laerdal Foundation for Acute Medicine
Mechanisms of Immunologic Dysfunction Induced by Hyperchloremic Metabolic Acidosis in Experimental Sepsis PI: John A Kellum, MD May 1, 2000 – Dec 31, 2001	Abbott Labs
Multicenter, Double-Blind, Placebo-Controlled, Randomized, Phase 3 Study of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor (rTFPI/SC-59735) in Severe Sepsis. PI: John A. Kellum, MD December 1, 2000 – November 03, 2001	Chiron Pharmaceuticals
Genetic and inflammatory markers of sepsis (GenIMS). PI: Derek Angus, MD, Co-PI: John A Kellum, MD GM61992-OlAl May 1, 2001 – April 30, 2005	National Institutes of Health R01
Blood Purification in Experimental Sepsis. PI: John A. Kellum, MD September 1, 2001 – August 31, 2003	Renal Tech International
Using Critical Analysis Skills in Authentic Problem Solving Situations:New Web-based Interactive Case Designs For Critical Care Physicians. PI: John A. Kellum, MD September 1, 2001 – August 31, 2002.	Eli Lilly and Company
A Phase Il Study to Determine the Efficacy and Safety of LY315920 in Patients with Severe Sepsis (J4A-MC-EZZI 5/14/01) (Amendment (a), 8/15/01), (CTP #JK01-001) PI: John A. Kellum, M.D January 1, 2002 through September 26, 2002.	Eli Lilly and Company
Intensive versus Conventional Renal Support in Acute Renal Failure. Acute Renal Failure Trial Network (ATN). 1/15/04-1/14/07. PI: Paul Palevsky, MD Co-I/Member, Executive Committee:John Kellum, M.D.	VA Cooperative Study Program National Institutes of Health (NIDDK)
Hemadsorption to Improve Donor Organ Recovery (HIDonOR) R38 0T01300 9/1/03-8/31/06 PI: John Kellum, M.D.	HRSA Division of Transplantation
A Hemadsorption Device for the Treatment of SIRS R41 GM69127 7/01/04-6/30/05 Co-PI: John Kellum, M.D.	National Institutes of Health (NIGMS)
Systems Engineering of a Pheresis Intervention for Sepsis (SEPsIS) HL080926: 10/1/05-9/30/10 PI: John Kellum, M.D.	National Institutes of Health (NHLBI)
Biological Markers of Recovery for the Kidney (BioMaRK) R01DK070910: 12/01/05-11/30/10 PI: John Kellum, M.D.	National Institutes of Health (NIDDK)

Current Research Interest:
Mechanisms of Organ Failure in Sepsis and Strategies to Reduce Organ Injury.
Acute Renal Failure
Hemofiltration in the treatment of multiple organ dysfunction and systemic inflammatory response
Acid-base Balance (in Critical Illness)
Metabolic Alterations in Sepsis and Critical Illness
Lactic Acidosis
Extracorporeal Organ Support in MODS
Clinical Epidemiology