| Titles:
Professor, Department of Critical Care Medicine
Associate Vice-Chancellor for Translational Research and Commercialization
Degrees:
Medical School: Washington University in St. Louis, Missouri,
MD, 1976, Medicine
Residency: National Naval Center in Bethesda, Maryland, MD, 1981,
Surgery
Board Certifications:
American Board of Surgery
Certificate of Added Qualifications in Surgical Critical Care
Recertification, American Board of Surgery
Recertification, Added Qualifications in Surgical Critical Care
Recertification, American Board of Surgery
Positions
1982-1984 Uniformed Services National Naval Medical Services (Bethesda,
MD), Assistant Professor of Surgery
1984-1986 University of Massachusetts Medical School (Worcester,
MA), Assistant Professor of Surgery/Anesthesiology
1986-1990 University of Massachusetts Medical School (Worcester,
MA), Associate Professor of Surgery/Anesthesiology
1987-1991 University of Massachusetts Graduate School (Worcester,
MA), Associate Professor of Physiology Program
1990-1991 University of Massachusetts Medical School (Worcester,
MA), Professor of Surgery and Anesthesiology
1992-1995 Harvard Medical School (Boston, MA), Associate Professor
of Surgery
1995-1999 Harvard Medical School (Boston, MA), Johnson and Johnson,
Professor of Surgery
1999-2000 University of Pittsburgh Medical School (Pittsburgh, PA),
Visiting Professor of Anesthesiology/CCM and
Surgery
2000-Pres University of Pittsburgh Medical School (Pittsburgh, PA),
Professor of Anesthesiology/CCM
2000-Pres University of Pittsburgh Medical School (Pittsburgh, PA),
Professor of Surgery
2000-Pres University of Pittsburgh Medical School (Pittsburgh, PA),
Watson Chair of Surgery
2001-Pres University of Pittsburgh Medical School (Pittsburgh, PA),
Member Faculty-(MIRM) McGowan Institute for
Regenerative Medicine
2001-Pres University of Pittsburgh Medical School (Pittsburgh, PA),
Chairman, Department of Critical Care Medicine
Honors:
Kraft Scholarship Award (University of California, Berkeley)
1966
Joint Service Commendation Medal 1973
Robert Carter Medical School Prize Washington University Medical
School) 1974
Richard S. Brookings Medical School Prize (Washington University
Medical School) 1975
Medical Alumni Scholarship Award (Washington University Medical
School) 1976
Robert Carter Medical School Prize Washington University Medical
School) 1977
Alpha Omega Alpha 1977
Alpha Omega Alpha Book Prize (Washington University Medical School)
1977
Merck Manual Award (Washington University Medical School) 1977
Laerdal Memorial Lecturer (Society of Critical Care Medicine) 1994
Invited Plenary Session Lecturer (Society of University Surgeons)
1994
Millenium Lecturer (Society of Critical Care Medicine) 2000
Presidential Citation Honor Lecture Award (American College of Chest
Physicians ACCP) 2001
Provosts Inaugural Lecture Series as Watson Chair in Surgery Presentation,
“Critical Care Medicine, Surgery, and…Ethyl Pyruvate”
2002
Research Grants
2 T32GM0780616 Academic Training in Trauma and Burns P.I. 1995-2000
NIH
2 R01 GM37631 Intestinal Perfusion and Permeability in sepsis P.I.
1996-2000 NIH
R01 GM39617 CAP-18/IgG Fusion Protein: A Novel Treatment for Co-P.I.
1997-2000 NIH
Sepsis
1RO1 GM58484 Molecular Mechanisms of Gut Barrier Dysfunction Co-P.I.
1999-2004 NIH
1RO1 GM59694 Bacterial Membrane Proteins in Gram-Negative Sepsis
Co-P.I. 2000-2004 NIH
1R43 GM59543 Polynitroxyl-dextran: Gut Protection Following Shock
Co-P.I. 2000 NIH
2RO1 GM37631 Intestinal Perfusion and Permeability in Sepsis P.I.
2000-2005 NIH
2P50 GM53789 Project IV: Gut Barrier Dysfunction in Hemorrhagic
P.I. 2000-2002 NIH
Shock
N65236-00-1-5434 Ringer’s Ethyl Pyruvate Solution (“REPS”)
as a Countermeasure for Overwhelming Infections Caused By Unconventional
Pathogens P.I. 2000-2003 DSRC
1R01 GM61992 Genetic and Inflammatory Markers of Sepsis Co-P.I.
2001-2004 NIH
N01-HR-16152 Clinical Centers for the Clinical Network for the Treatment
of the Adult Respiratory Distress Syndrome (ARDSnet) Co-P.I. 2000-2003
NIH
105473 Pathogenesis of Experimental Necrotizing Enterocolitis Co-PI
2002-2003 NIH
Research Interests:
1. Pathogensis of organ failure in sepsis.
2. Cytokine-induced alterations in epithelial barrier function
3. Development of novel therapeutic agents for sepsis.
4. Sepsis-induced alterations in mitochondrial function.
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