| Titles:
Associate Professor of Critical Care Medicine
Associate Professor of Pathology
Faculty, Clinical Research and Systems Modeling Of Acute Illness (CRISMA) Lab
Adjunct Faculty, McGowen Institute for Regenerative Medicine (MIRM)
Contact:
Email: deluder@upmc.edu
Degrees:
POST GRADUATE EDUCATION
INSTITUTION AND LOCATION |
DEGREE |
YEAR |
FIELD |
| Vanderbilt University |
PhD |
1992 |
Molecular Biology |
Fellowship:
|
|
| Boston University School of Medicine |
Postdoc |
1997 |
Immunology/Infectious Diseases |
Administrative Title:
Research Grants:
| Title |
Source of Support |
| Perfusion and permeability in sepsis |
NIGMS |
| Ethyl pyruvate: a novel treatment for sepsis |
NIGMS |
| A small volume mitochondrial cocktail to delay development of irreversibility in combat casualties - PI |
DARPA |
| Gut barrier dysfunction in hemorrhagic shock - Co-PI |
NIGMS |
| Protocolized care of early septic shock - Co-I |
NIGMS |
Current Research Interest:
- Septic and hemorrhagic shock
- Systemic inflammation
- Multiple organ dysfunction
- RAGE/HMGB1 signal transduction
- Molecular pathology of community acquired
pneumonia
Publications:
1. Macias CA, Chiao JW, Xiao J, et al. Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Ann Surg. 2007; 245:305-314.
2. Angus DC, Yang L, Kong L, et al. Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med. 2007; 35:1061-1067.
3. Liu S, Stolz DB, Sappington PL, et al. HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers. Am J Physiol Cell Physiol. 2006; 290:C990-999.
4. Han Y, Englert JA, Yang R, Delude RL, Fink MP. Ethyl pyruvate inhibits nuclear factor-kB-dependent signaling by directly targeting p65. J Pharmacol Exp Ther. 2005; 312:1097-1105.
5. Fink MP, Delude RL. Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin. 2005; 21:177-196.
6. Han X, Fink MP, Uchiyama T, Yang R, Delude RL. Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice. Am J Physiol Lung Cell Mol Physiol. 2004; 286:L259-267.
7. Han X, Fink MP, Uchiyama T, Yang R, Delude RL. Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice. Am J Physiol Gastrointest Liver Physiol. 2004; 286:G126-136.
Presentations at Major Meetings:
- Yende S, Kong L, Weissfeld L, Kellum JA, Fink MP, Pinsky MR, Delude RL, Angus DC. Inflammatory markers prior to hospital discharge predict subsequent mortality after community acquired pneumonia (CAP). Proc Am Thorac Soc 2006, 3:A836.
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