Titles:
Associate Professor, CCM

Contact:
Email: clermontg@upmc.edu

Degrees:

Administrative Titles:

• Medical Director, Center for Inflammation and Regenerative Modeling, University of Pittsburgh.
• Co-Director, Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Laboratory, University of Pittsburgh.
• Vice-President, The Society for Complexity in Acute Illness (SCAI) www.scai-med.org
• Program Director:  International Conference on Complexity in Acute Illness (ICCAI) www.iccai.org.
• Training Program Affiliated Faculty, Center for Biomedical Informatics, University of Pittsburgh.
• Course Co-Director: "MSCMP3790. A Systems Approach to Inflammation," University of Pittsburgh School of Medicine.
• Course Co-Director: "BIOINF3115. Mathematical Modeling Techniques," University of Pittsburgh School of Medicine.
• Lecturer/Instructor: "COMPBIO2040. Cell and Systems Modeling core class," University of Pittsburgh School of Medicine.

Major Honors/Awards:

• 1998 ACCP Young Investigator Award (American College of Chest Physicians)
• 2000 Founder’s Grant in Health Services Research (Society of Critical Care Medicine)

Research Grants:

Research Interests:

• Epidemiology and economics of critical illness and health care delivery.
• Cost-effectiveness assessment.
• Mathematical modeling of critical illness including survival analysis, risk assessment, and mechanisms of sepsis and organ failure.

Publications:

• Clermont G, Comptois R. Case report: Hyponatremia of obscure etiology. L’Union Médicale du Canada 120(5), September/October 1991.
• Ghattas G, Clermont G. Case report: New onset diabetes heralded by pruritus. L’Union Médicale du Canada 121(4), July/August 1992.
• Angus DC, Sirio CA, Clermont G, Bion J. International Comparisons of Critical Care Outcome and Resource Consumption. Crit Care Clin 1997,9:2;389-408.
• Clermont G, Angus DC, Linde-Zwirble WT, Lave JR, Pinsky, MR. Measuring Resource Use in the ICU with Computerized Therapeutic Intervention Scoring System-Based Data. Chest 1998, 113:434-442.
• Clermont G, Angus DC. Severity scoring systems in the modern intensive care unit. Annals Academy of Medicine of Singapore 1998; 27:397-403.
• Angus DC, Clermont G, Kramer DJ, Linde-Zwirble WT, Pinsky MR. Short and Long-term Outcome Prediction with the APACHE II System after Orthotopic Liver Transplantation. Crit Care Med 2000, 28(1):150-156.
• Kayaalp M, Cooper GF, Clermont G. Predicting ICU Morality: A comparison of Stationary and Nonstationary Temporal Models.  Proceedings of the American Medical Informatics Association (AMIA) Annual Symposium 2000;418-22.
• Clermont GC, Angus DC, DiRusso SM, Griffin M, Linde-Zwirble WT. Predicting hospital mortality for ICU Patients: A comparison of artificial neural networks with logistic regression models Crit Care Med 2001;29:291-296.
• Angus DC, Musthafa AA, Clermont G, Griffin MF, Linde-Zwirble WT, Dremsizov TT, Pinsky MR. Quality-adjusted survival in the first year after the acute respiratory distress syndrome.  Am J Respir Crit Care Med 2001;163:1389-1394.
• Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of Severe Sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-1310.
• Angus DC, Linde-Zwirble WT, Clermont G, Griffin MF, Clark RH. Epidemiology of Neonatal Respiratory Failure in the United States:  Projections from California and New York. Am J. Respir Crit Care Med 2001 Nov;164(7):1154-1160.
• Clermont G, Angus DC, Linde-Zwirble WT, Griffin MF, Fine MJ, Pinsky MR. Does Acute Organ Dysfunction Predict Patient Centered Outcomes? Chest Jun 2002; 121(6):1963-1971.
• Kaplan V, Angus DC, Griffin MF, Clermont G, Watson RS, Linde-Zwirble WT. Hospitalized Community-acquired Pneumonia in the Elderly: Age- and sex-related patterns of care and outcome in the United States Am J Respir Crit Care Med  March 2002;165(6):766-772.
• Angus DC, Marrie TJ, Obrosky DS, Clermont G, Dremsizov T, Coley C, Fine MJ, Singer DE, Kapoor WN. Severe community-acquired pneumonia: Use of intensive care and evaluation of the ATS criteria. Am J Respir Crit Care Med 2002; 166:717-723.
• Clermont G, Acker C,  Angus D,  Sirio C, Pinsky M, Johnson J.  Renal failure in the ICU: Comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes. Kidney International Sept 2002; 62(3):986-996.
• Angus DC, Linde-Zwirble WT, Clermont G, Ball DE, Basson BR, Ely EW, Laterre PF, Vincent JL, Bernard G, van Hout, B, for the PROWESS Investigators.  Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Critical Care Medicine 2003, 31(1):1-11.
• Kaplan V, Clermont G, Griffin MF, Kasal J, Watson RS, Linde-Zwirble WT, Angus DC. Pneumonia – still the old man’s friend Pu? Archives of Internal Medicine  2003, 163:317-323.
• Watson, RS, Carrcillo, JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Respir Critical Care Medicine 2003; 167- 695-701
• Clermont G, Kalassian KG, Angus DC,  Linde-Zwirble WT, Ramakrishnan N, Linden PK, Pinsky MR.  Reassessing the value of short-term mortality in sepsis: comparing conventional approaches to modeling. Crit Care Med 2003; 31:2627-2633.
• Angus DC, Clermont G, Watson RS, Linde-Zwirble WT, Clark RH, Roberts MS.  Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the US.  Pediatrics  2003; 112:1351-1360.
• Kasal J, Jovanovic Z, Clermont G, Weissfeld LA, Kaplan V, Watson R, Angus DC.  A comparison of Cox and Gray’s survival models in severe sepsis.Crit Care Med  2004; 32:700-707.
• Clermont G, Bartels J, Kumar R, Constantine G, Vodovotz Y, Chow C.  In Silico design of clinical trials: A method coming of age.  Critical Care Med  2004; 32(10):2061-2070.
• Vodovotz Y, Clermont G, Chow CC, An G.  Mathematical models of the acute inflammatory response.  Current Opinion 2004; 10(5):383-390.
• Laterre P, Levy H, Clermont G, Ball DE, Garg R, Nelson DR, Dhainaut J, Angus D.  Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Trial.  Crit Care Med 2004; 32(11):2207-2218.
• Clermont G, Kaplan V, Moreno R, Vincent J, Linde-Zwirble WT, Van Hout BV, Angus DC.  Dynamic microsimulation to model multiple outcomes in cohorts of critically ill patients.  Intensive Care Med  2004; 30:2237-2244.
• Milbrandt EB, Kersten A, Kong L, Weissfeld LA, Clermont G, Fink MP, Angus DC.  Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients.  Critical Care Med  Jan 2005; 33(1):226-229.
• Kumar R, Clermont G, Vodovotz Y, Chow CC.  The dynamics of acute inflammation.  J Theoretical Biology 2004; 230:145-155.
• Clermont G, Chow CC, Kumar R, Lagoa C, Tawadrous Z, Gallo D, Bitten B, Bartels J, Constantine C, Fink MP, Billiar TR, Vodovotz Y. The acute inflammatory response in diverse shock states,  Shock 2005 Jul; 24(1):74-84.
• Al-Nakeeb S, Clermont G.  Procalcitonin testing has the potential to reduce unnecessary antibiotic use in patients with suspected lower respiratory tract infections. Crit Care  2005 Feb 17;9(3):E5.
• Whitcomb DC, Aoun E, Vodovotz Y, Clermont G, Barmada MM.  Evaluating disorders with a complex genetics basis.  The future roles of meta-analysis and systems biology.  Digestive Diseases and Sciences  2005 50(12):2195-2202.
• Dremsizov T, Clermont G, Kellum JA, Kalassian KG, Fine MJ, Angus DC.  Severe sepsis in community-acquired pneumonia: When does it happen and do SIRS criteria help predict course?  Chest 2006; 129:968-978.
• Milbrandt EB, Clermont G, Martinez J, Kersten A, Rahim MT, Angus DC.  Predicting late anemia in critical illness.  Critical Care  2006; 10:R39.
• Constantine G, Clermont G.  Colorful isomorphic spanning trees in complete graphs.  Annals of Combinatorics  2005; 9:163-167.
• Reynolds A, Rubin J, Clermont G, Day J, Vodovotz Y, Ermentrout G.   A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol  2006 Apr 5.
• Day J, Rubin J, Vodovotz Y, Chow CC, Reynolds A, Clermont G.  A reduced mathematical model of the acute inflammatory resposne: II.  Capturing scenarios of repeated endotoxin administration. J Theor Biol  2006 Apr 5.
• Vodovotz Y, Chow CC, Bartels J, Lagoa C, Kumar R, Day J, Rubin J, Constantine G, Billiar TR, Fink MP, Clermont G.  In Silico models of acute inflammation in animals.  Shock  2006; 26:235-244.
• Galhotra S, Scholle CC, Dew MA, Mininni NC, Clermont G, DeVita MA.  Medical emergency teams: A strategy for improving patient care and nursing work environments.  J Advanced Nursing 2006; 55(2):180-187.
• Hoste EAJ, Clermont G, Kersten A, Vekataraman R, Angus DC, De Bacquer D, Kellum JA.  RIFLE criteria for acute kidney injury is associated with hospital mortality in critically ill patients: A cohort analysis.  Critical Care  (in press).
• Prince J, Levy R, Bartels J, Baratt A, Kane J, Lagoa C, Rubin J, Day J, Wei J, Fink M, Goyert S, Clermont G, Billiar T.  In Silico and In Vivo approach to elucidate the inflammatory complexity of CD14-deficient mice.  Molecular Medicine 2006; 12:88-96.
• Angus DC, Clermont G, Linde-Zwirble WT, Musthafa AA, Dremsizov TT, Lidicker J, Lave JR.  Healthcare costs and long-term outcomes after ARDS:  A phase III trial of inhaled nitric oxide.  Crit Care Med 2006; 34(12):2883-90.
• Lagoa CE, Bartels J, Barratt A, Tseng G, Clermont G, Fink MP, Billiar TR, Vodovotz Y.  The role of initial trauma in the host’s response to injury and hemorrhage: Insights from a comparison of mathematical simulations and genomics.  SHOCK  2006; 26(6):592-600.
• Upperman JS, Camerini V, Lugo B, Yotov I, Sullivan J, Rubin J, Clermont G, Zamora R, Ermentrout GB, Ford HR, Vodovotz Y.  Mathematical modeling in necrotizing enterocolitis – a new look at an ongoing problem.  J Ped Surgery 2006 (in press).
• Hancioglu B, Swigon D, Clermont G.  A dynamical model of human immune response to influenza virus infection.  J Theoretical Biology 2006 (in press).
  Vodovotz Y, Clermont G, An G, Hunt CA, Lefering R, Bartels J, Seydel R, Hotchkiss J, Brause R, Ta’asan S, Neugebauer E. Evidence-based modeling of critical illness: An initial consensus from the Society for Complexity in Acute Illness.  J Crit Care 2006 (in press).
• Huang DT, Clermont G, Sexton JB, Karlo CA, Miller RG, Weissfeld LA, Rowan KM, Angus DC.  Perceptions of safety culture vary across the intensive care units of a single institution.  Crit Care Med 2007 Jan; 34(1):165-76.
• Kumar R, Chow CC, Bartels JD, Clermont G, Vodovotz Y.  A mathematical simulation of the inflammatory response to Anthrax infection. SHOCK 2007 (in press).

Presentations at Major Meetings:

• 10/93,  Lecturer:  “Cerebral Whipple’s Disease,” Medical Grand Rounds, Department of Internal Medicine, Hôpital du Sacré-Coeur, Université de Montréal, Montréal, QC.
• 04/96, Invited Lecturer:  “Analysis of European and Japanese Incidence of ARDS,”  Pharmaco-economic Review, Ohmeda Pharmaceuticals, Inc., Liberty Corner, NJ.
• 04/00, Invited Lecturer: “L’efficience in Soins Intensifs,” Medical Grand Rounds, University of Montreal Hospital Center, Montreal, QC.
• 6/01, Invited Lecturer:  “Cost-Effectiveness in Critical Care: Inhaled NO in Neonates with Hypoxic Respiratory Failure,” Grand Rounds, University of Pittsburgh Medical Center – Magee Hospital, Pittsburgh, PA.
• 11/02, Invited Lecturer:  “Cost-Effectiveness in Critical Care,” Chest 2002, Annual Meeting of the American College of Chest Physician.
• 11/02, Invited Lecturer:  “The Prognosis of the Sepsis,” Chest 2002, Annual Meeting of the American College of Chest Physician.
• 2/03,  Invited Lecturer:  “Application of Modeling to Clinical Practice and Therapeutics,”  2nd Workshop on Complex  Symptoms Analysis on Shock and Trauma.
• 10/6/03, Invited Lecturer:  “The Impact of EGDT on Cost and Mortality, Early Goal Directed Therapy and Management of the Septic Patient,” sponsored by the European Society of Intensive Care Medicine.  Amsterdam, Netherlands.
• 11/4/03, Lecturer:  “Dynamical Systems Model of Systemic Inflammation: Simulated Population Studies and Clinical Trials,” Complex Systems in Critical Illness Workshop, Pittsburgh, PA.
• 3/4/04, Invited Lecturer:  “Application of the Model to Clinical Trials,” 6th World Congress on Trauma, Shock, Inflammation and Sepsis – Pathophysiology, Immune Consequences and Therapy, Munich, Germany.
• 3/2/04, Lecturer:  “Quantitative Dynamics of Acute Inflammation,” Critical Care Medicine Grand/Research Conference, University of Pittsburgh School of Medicine, Pittsburgh, PA.
• 3/25/04, Invited Lecturer:  “Cost Effectiveness of Inhaled Nitric Oxide in the Treatment of Neonatal Respiratory Failure,” Controversies in Maternal Child Health Care sponsored by the Louisiana Perinatal/MCH Foundation and the Louisiana Maternal and Child Health Coalition, New   Orleans, LA.
• 7/16/04, Invited Lecturer:  “Mathematical Modeling of Acute Inflammation,” The 2004 Meeting of the International Federation of Classification Societies, Illinois Institute of Technology, Chicago, IL.
• 11/9/04, Invited Lecturer:  “In Silico Clinical Trial Design: Lessons and Directions,” International Conference on Complexity in Acute Illness, Pittsburgh, PA.
• 9/14/06,  Invited Lecturer: “Applications of biosimulations to translational research,”  12th Congress of the European Shock Society (ESS), Ulm Germany.
• 10/5/06,  Invited Lecturer: “Systems modeling of inflammation,” Medical Grand Rounds, Albert Einstein College of Medicine, New York, NY.
• 10/5/06, Invited Lecturer: “Systems biology in acute illness: From bench to bedside,” Medical Grand Rounds, Montefiore Medical Center, New York, NY.
• 10/10/06,  Invited Lecturer: “To Kill or not to Kill – Decision making in Natural Killer Cells,” Systems Immunology Session Talk, The 7th International Conference on Systems Biology (ICSB-2006), Yokohama Japan.
• 10/19/06, Invited Lecturer: “A clinician’s perspective on systems biology,” Systems Biology and Complexity Session Talk, The 5th International Conference on Complexity in Acute Illness (ICCAI), Washington, DC.
• 9/14/06, Invited Lecturer: “Applications of biosimulations to translational research,”  12th Congress of the European Shock Society (ESS), Ulm Germany.
• 10/5/06, Invited Lecturer: “Systems modeling of inflammation,” Medical Grand Rounds, Albert Einstein College of Medicine, New York, NY.
• 10/5/06, Invited Lecturer: “Systems biology in acute illness: From bench to bedside,” Medical Grand Rounds, Montefiore Medical Center, New York, NY.
• 10/10/06, Invited Lecturer: “To Kill or not to Kill – Decision making in Natural Killer Cells,” Systems Immunology Session Talk, The 7th International Conference on Systems Biology (ICSB-2006), Yokohama Japan.
• 10/19/06, Invited Lecturer: “A clinician’s perspective on systems biology,” Systems Biology and Complexity Session Talk, The 5th International Conference on Complexity in Acute Illness (ICCAI), Washington, DC.
• 3/15/07, Invited Lecturer:  “Mathematical models simulating clinical trials,” 7th World Congress on Trauma, Shock, Inflammation and Sepsis, Munich, Germany.
• 3/24/07, Invited Lecturer:  “Complexity in Critical Illness,”  HIT 2007 – The Intensive Care Symposium, Hamburg, Germany.

06-Jun-2007 dmk