| Titles:
Associate Professor, CCM and Pediatrics
Contact:
Email: clarkrs@ccm.upmc.edu
Degrees:
POST GRADUATE EDUCATION
INSTITUTION AND LOCATION |
DEGREE |
YEAR |
FIELD |
| Medical College of Wisconsin |
MD |
1989 |
Medicine |
| Residency: |
|
| University of Utah Affiliated Hospitals |
Resident |
1992 |
Pediatrics |
Fellowship:
|
|
| Children’s Hospital of Pittsburgh, Safar Center for
Resuscitation Research |
Fellow |
1995 |
Pediatric Critical Care Medicine Research |
| Board Certifications: |
Year |
Pediatrics
|
1992 |
| Pediatric Critical Care Medicine |
1995 |
Administrative Title:
- Program Director, Pediatric Critical Care Medicine
fellowship, Children’s Hospital of Pittsburgh
- Associate Director, Molecular Biology, Safar
Center for Resuscitation Research, University of Pittsburgh
Major Honors/Awards:
- National Institutes of Health Pediatrician
Scientist Development Award (1998)
- National Institutes of Health Clinical Investigator
Award (1996-2001)
- Society of Critical Care Medicine Neuroscience
Award (1998)
- Society of Critical Care Medicine Presidential
Citation (2001)
- Society of Critical Care Medicine Presidential
Citation (2002)
Research Grants:
| Title |
Source of Support |
| Role of Neuroprotective Genes After Traumatic Brain |
NIH/NINDS KO8 NS01946 (1996-2001) |
| InjuryCaspase-Mediated Neuronal Death After Head |
NIH/NINDS RO1 NS38620 (1999-2003) |
| InjuryPARS Activation After Traumatic Brain |
NIH/NINDS P50 NS30318 (2000-05) |
| InjuryDivergent Pathways of Cell Death After Brain |
NIH/NINDS RO1 NS38620 (2003-2008) |
| InjuryUltrapotent PARS Inhibitor for CNS Trauma |
NIH SBRI Subcontract (2002-03) |
Current Research Interest:
- Cell death and survival pathways after brain
injury
- Traumatic brain injury
- Pediatric cardiopulmonary arrest
- Pediatric neurointensive care
Publications:
- Clark RSB, Chen J, Watkins SC, Kochanek PM,
Chen M, Loeffert JE, Stetler RA, Graham SH: Apoptosis suppressor
gene bcl-2 expression after traumatic brain injury in rats. J
Neurosci 17:9172-9182, 1997.
- Clark RSB, Kochanek PM, Chen M, Watkins SC,
Marion DW, Hamilton RL, Chen J, Loeffert JE, Graham SH: Increase
in Bcl-2 and cleavage of Caspase-1 and Caspase-3 in human brain
after head injury. FASEB J 13:813-821, 1999.
- Clark RSB, Kochanek PM, Adelson PD, Bell MJ,
Carcillo JA, Chen M, Wisniewski SR, Janesko K, Whalen MJ, Graham
SH: Increases in bcl-2 protein in cerebrospinal fluid and evidence
for programmed-cell death in infants and children following severe
traumatic brain injury. J Pediatr 137:197-204, 2000.
- RSB Clark and PM Kochanek, eds. Brain Injury:
Molecular and Cellular Biology of Critical Care Medicine,
Kluwer Academic Publishers, Boston, 400 pages, 2001.
- Zhang X, Chen J, Graham SH, Du L, Kochanek
PM, Draviam R, Guo F, Nathaniel PD, Szabo C, Watkins SC, Clark
RSB: Intranuclear localization of apoptosis-inducing factor and
large scale DNA fragmentation after traumatic brain in rats and
in neuronal cultures exposed to peroxynitrite. J Neurochem,
82:181-191, 2002.
Presentations at Major Meetings:
- Jan. 25, 2002 Pathophysiology of Traumatic
Brain Injury
Current Concepts in Pediatric Critical Care 2002
San Diego, CA
- April 9, 2002 Central Nervous System Structure
and Function and
Head and Spinal Cord Trauma, Increased ICP, Brain Death
Pediatric Critical Care Medicine 2002: A Review for Board Preparation
and Comprehensive Update. Center for Bio-Medical Communications,
Inc.
Washington, D.C.
- Jan. 29, 2002 Clinical Application of Molecular
Biology to Neurointensive Care
Society of Critical Care Medicine 31st Educational and Scientific
Symposium
San Diego, CA
- Mar. 11, 2002 Divergent Pathways of Cell Death
After Brain Injury
1st Annual Symposium of the Pittsburgh Institute for Neurodegenerative
Diseases
Pittsburgh, PA
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