Joseph A. Carcillo, MD
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Titles:
Associate Professor, CCM and Pediatrics

Contact:
Email: carcilloja@ccm.upmc.edu

Degrees:

POST GRADUATE EDUCATION
INSTITUTION AND LOCATION
DEGREE YEAR FIELD
Medical School: George Washington University
MD 1978-1982
Medicine
Residency:  
Children’s Hospital National Medical Center, Washington University, Washington, DC Resident 1982-1985 Pediatrics
Fellowship:
 
Children’s Hospital National Medical Center, Washington University, Washington, DC Fellow 1985-1987 Pediatrics
Board Certifications: Year
National Board of Pediatrics
1986
National Board of Pediatric Critical Care Medicine 1987
ABP Recertification PCCM 1995
National Board of Pediatric Critical Care Medicine 1995

Major Honors/Awards:

  • 1976 High Honors Thesis in Biology, Wesleyan University Honor College
  • 1982 Sandoz Psychiatry Award, George Washington University
  • 1982 Lange Publication Award, George Washington University
  • 1982 Alpha Omega Alpha Honor Society, George Washington University
  • 1987 16th Annual Scientific Education Symposium
  • 1987 Burton Epstein Award for Outstanding Fellow in Pediatric
    Critical Care Medicine, Children's National Medical Center, Washington, D.C.
  • 1995 Fellow, American Academy of Pediatrics
  • 1996 Society For Critical Care Medicine Program Committee
  • 1997 Society For Critical Care Medicine Program Committee
  • 1997 Member Society for Pediatric Research (SPR)
  • 1998 Society For Critical Care Medicine Program Committee
  • 1998 Member Critical Care Medicine Editorial Board
  • 1999 Program Chairperson SCCM Scientific & Educational Symposium

Research Grants:

Title Source of Support
RFA-HL-02-001 Darrell J. Triulzi, MD (PI) 9/30/02 – 9/29/07

Transfusion Medicine/Hemostasis Clinical Research Network

This network will promote the efficient comparison of novel management strategies of potential benefit for children and adults with hemostatic disorders such as idiopathic thrombocytopenia (ITP) and thrombotic thrombocytopenic purpura (TTP) and lso will evaluate novel as well as existing blood products and cytokines for the treatment of hematologic disorders. The objective of this Request for Applications (RFA) is to establish and maintain (1) the infrastructure required for a network of up to sixteen core clinical centers to perform multiple clinical trials and (2) a Data Coordinating Center for the Network.

(Pending)
NIH
3M01RR000056, Thomas Detre (PI) 12/1/97 – 11/30/00

CAP-GCRC CYP 2D6 PMBMC mRNA and Whole Body CYP2D6 Metabolic Activity in Humans

The objectives of the GCRC at UPMC are to provide an essential resource to elucidate mechanisms involved in the pathophysiology of disease states, develop and evaluate novel therapeutic strategies, teach potential clinical investigators, and integrate basic science with clinical medicine.

NIH

Current Research Interest:

  • Pediatric sepsis and MODS

Publications:

(Shock)

  • Carcillo JA, Davis AL, Zaritsky A: Role of early fluid resuscitation in pediatric septic shock. JAMA 266(9):1242-1245, 1991.
  • Ceneviva G, Paschall JA, Maffei F, Carcillo JA: Hemodynamic support in fluid-refractory pediatric septic shock. Pediatrics 102(2):e19, 1998.
  • Carcillo JA: Task Force Members, Fields AI. Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med 30(6):1-13, 2002.

(Epidemiology)

  • Angus D, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky M: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29(7):1303-1310, 2001.
  • Watson RS, Carcillo J, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in newborns, infants, and children in the US. American Journal of Respiratory and Critical Care Medicine. In press.

(MODS)

  • Doughty LA, Kaplan SS, Carcillo JA: Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Crit Care Med 24(7): 1137-1143, 1996.
  • Doughty L, Carcillo JA, Kaplan S, Janosky J: Plasma nitrite and nitrate concentrations and multiple organ failure in pediatric sepsis. Crit Care Med 26(1):157-62, 1998.
  • Green J, Doughty L, Kaplan SS, Sasser H, Carcillo JA: The tissue factor and plasminogen activator inhibitor type 1 response in pediatric sepsis induced multiple organ failure Thromb Haemost 87(2):218-23, 2002.
  • Doughty L, Clark RSB, Kaplan SS, Sasser H, Carcillo J: sFas and sFas ligand and pediatric sepsis- induced multiple organ failure syndrome. Pediatr Res 52(6):922-927, 2002.

(Both)

  • Carcillo JA, Cunnion RE: Septic Shock. Crit Care Clin 13(3):553-74, 1997.
  • Carcillo JA. Septic shock and MODS. Crit Care Clin, 2002, in press.

Presentations at Major Meetings:

  • 2001 Immune paralysis in children
    World Congress in Intensive Care and Emergency Medicine
    Brussels, Belgium
  • 2001 Management of Pediatric Septic Shock
    World Congress in Intensive Care and Emergency Medicine
    Brussels, Belgium
  • 2001 Drug Therapy in the Pediatric ICU
    World Congress in Intensive Care and Emergency Medicine
    Brussels, Belgium
  • 2002 Plasma exchange therapy for thrombosis and bleeding
    Society for Critical Care Medicine
    San Diego, California
  • 2002 Management of Pediatric Septic Shock
    3rd National Congress on Childhood Emergencies
    Dallas, Texas