Titles:
Associate Professor of Pediatrics and Critical Care Medicine

Contact:
Email: bellmj4@upmc.edu

Degrees:

Administrative Title:

• Director, Neurocritical Care

Major Honors/Awards:

• 2002 Departmental Teaching Award for Teaching Excellence
  Presented by the House Staff of Children’s National Medical Center
• 2004 Departmental Teaching Award for Teaching Excellence
  Presented by the House Staff of Children’s National Medical Center

Research Grants:

Current Research Interest:

• Clinical: Identifying occult neurological injuries; Performing single- or multicenter trials to develop neuroprotective strategies to mitigate brain injuries; Developing Pediatric Neurocritical Care as a subspecialty of Pediatrics; Establishing a multi-institutional, Pediatric Neurocritical Care Research Network
• Laboratory: Understanding the effects of inflammation on both developing brain and progenitor cells; Ultimately, linking inflammation and brain development from laboratory work to clinical setting

Publications:

• Bell MJ, Robertson CS, Kochanek PM, Goodman JC, Gopinpath S, Carcillo JA, Clark RSB, Marion DW, Mi Z, Jackson EK. “Interstitial Brain Adenosine is Increased During Jugular Venous Desaturations in Humans after Traumatic Brain Injury: Evidence of Energy Failure.” Crit Care Med 29(2): 399-404, 2001.
• Bell MJ and Hallenbeck JM. “The Effects of Intrauterine Inflammation on Developing Rat Brain.” J Neurosci Res 70: 570-9, 2002.
• Bell MJ, Hallenbeck JM, Gallo V. “Determining the Fetal Inflammatory Response in an Experimental Model of Intrauterine Inflammation.” Pediatr Res 56(1): 541-6, 2004.
• Sharangpani A and Bell MJ. “Fas and Caspase Activation in Fetal Rat Brain Following Experimental Intrauterine Inflammation”. Brain Res 2007 (in press).
• Hsu AA, Fenton K, Weinstein S, Carpenter J, Dalton H and Bell MJ. “Neurological Injury Markers in Children with Septic Shock”. Pediatr Crit Care 2007 (in press).

Presentations at Major Meetings:

• Takanohashi A, Bell MJ. “Microglia are Activated after Perinatal Lipopolysaccharide (LPS) Stimulation in Mice and Rats.” Soc for Neurosci Abstracts 2006 (in press).
• Bell MJ, Takanohashi A. “Perinatal Inflammation Effects on Proliferation and Cell Death in Mice.” Soc for Neurosci Abstracts 2006 (in press).
• Sharangpani A, Bell MJ. “Tumor Necrosis Factor (TNF) and Lipopolysaccharide (LPS) are Not Toxic to Human Neural Stem Cells (HNSC) in vitro.” Soc for Neurosci Abstracts 2006 (in press).
• Sharangpani A, Bell MJ. “Activation of Human Microglia Causes Decreased Human Neural Stem Cell Proliferation.” Crit Care Med (34)12: A38, 2007.
• Subbaswamy A, Hsu AA, Bell MJ. “Correlation of Cerebral Near-infrared Spectroscopy (cNIRS) with Serological Markers of Neurological Injury in Critically-ill Children.” Soc for Pediatr Res 2007 (Program No. 5330.10 2007 Abstract Viewer/Itinerary Planner).
• Bell MJ, Carpenter J, Weinstein S. “Development of Pediatric Neurocritical Care Service.” Crit Care Med (submitted).
• Takanohashi A and Bell MJ. “Microglial Activation after Perinatal Inflammation is Corticosteroid-Dependent”, Crit Care Med (submitted).
• Bell MJ. “Oligodendrocyte Proliferation after Perinatal Inflammation”, Crit Care Med (submitted).
• Subbaswamy A, Hsu AA, Bell MJ. “Near-infrared Spectroscopy Correlates with Neurological Markers in Children with Known Neurological Injuries”. Crit Care Med (submitted).