Titles:
Professor and Chair, Critical Care Medicine
Professor, Medicine and Health Policy and Management

Contact:
Email: angusdc@ccm.upmc.edu

Biography Summary:

Derek Angus was recruited to the CCM Fellowship after residency in internal medicine at the University of Glasgow in the UK. Dr. Grenvik was an invited lecturer, when his co-editor of a CCM book series, Professor Iain McA Ledingham, a renowned British intensivist and ICU Director at Glasgow’s Western Infirmary, singled out Dr. Angus as his, by far, best trainee and recommended him for further CCM training in Pittsburgh. Derek started his clinical CCM fellowship at UPMC in 1989, followed by a year of research at the Safar Center. During this time, he also obtained his MPH at the University of Pittsburgh School of Public Health. Derek's many talents were obvious to us from the onset and he was appointed to the CCM Faculty in 1992. Through his productive research and excellent publications in our most prominent journals, he rapidly escalated to full professor. In 2001, he was appointed vice chair for research in the then new and independent Department of CCM, still unique in the US as the only such academic department in the country. This department has grown enormously and now has a total of 18 full professors among a faculty of approximately 80 members. Dr. Angus has contributed immensely to the thousands of prominent publications by our faculty, responsible also for over 30 books, since becoming a separate department.

Degrees:

Administrative Title

• 1992-1998 Assistant Professor of Anesthesiology, University of Pittsburgh, School of Medicine
• 1992- Attending, Department of Anesthesiology/CCM, University of Pittsburgh Medical Center
• 1994-1998 Assistant Professor of Medicine, University of Pittsburgh, School of Medicine (secondary appointment)
• 1998- Associate Professor of Anesthesiology and Critical Care Medicine, University of Pittsburgh, School of Medicine
• 1998- Associate Professor of Medicine, University of Pittsburgh, School of Medicine (secondary appointment)
• 2000-2003 Associate Professor of Health Services Administration, University of Pittsburgh, Graduate School of Public Health (secondary appointment)
• 2001- Vice Chair for Research, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine
• 2008- Professor and Chair, Department of Critical Care Medicine

Honors:
1994 Fellow, American College of Chest Physicians (FCCP)
1995 Young Investigator Award, American College of Chest Physicians
1996 Co-author, Young Investigator Award, American College of Chest Physicians
1997 Fellow, American College of Critical Care Medicine (FCCM)
1998 Co-author, Young Investigator Award, American College of Chest Physicians
1999 Internal Medicine Specialty Research Award, Society of Critical Care Medicine
1999 Council Member, Pan-American Iberian Federation of Intensive Care Societies
2001 Senior author, Pediatrics Specialty Research Award, Society of Critical Care Medicine
2001 Senior author, Industry Specialty Research Award, Society of Critical Care Medicine
2001 Senior author, Best Original Research Award, Society of Critical Care Medicine
2001 Chairman’s Citation, American Thoracic Society
2001 The Annual Gregory Mark Taubin Lecturer, Children's National Medical Center, Washington, DC

Research Support:

Ongoing
1 R01 GM61992-01 Angus DC, PI 4/01/01 - 3/31/05 Principal Investigator
NIGMS
Genetic and Inflammatory Markers of Sepsis
Major goal of this project: To determine the influence of specific polymorphisms on the development, course and outcome of pneumonia and sepsis.

1 R01 HL69991-01 Angus DC, PI 12/1/02 – 11/30/07 Principal Investigator
NHLBI
Prolonged outcomes after nitric oxide for ventilated premature newborns
Major goal of this project: We extend and enhance the follow-up of a randomized controlled trial that will assess the effect of iNO on a combined end-point of mortality or oxygen dependency at 36 weeks post-conceptional age in 800 infants with prematurity-associated respiratory failure. We aim to assess the effects of iNO use on long-term (up to school age) clinical and childhood developmental outcomes; family burden; and healthcare costs of prematurity-associated respiratory failure, including the cost-effectiveness of iNO in ventilated premature infants.

1 R01 HS/HL11620-01 Angus DC, PI 9/30/01 – 8/31/05 Principal Investigator
AHRQ/NHLBI
Economic Analysis of the Pulmonary Artery Catheter Use
Major goal of this project: We complement the Fluid and Catheter Treatment Trial (N01-HR-46054-46064) with a concurrent economic analysis of the pulmonary artery catheter. Our aims are to compare differences between study arms in long-term survival, quality of life, and quality-adjusted survival, to compare differences between study arms in acute care and long-term costs, and to calculate the cost-efficacy and estimate the cost-effectiveness of PAC under 'real-world" conditions.

1 T32 HD40686 Kochanek P, PI 9/25/00 – 4/30/05 Co-Investigator
NICHHD
Pediatric Neurointensive Care and Resuscitation Research
Major goal of this project: This postdoctoral program will train pediatric critical care medicine, neurological surgery and neurology fellows in basic and clinical research focused on neurointensive care and cerebral resuscitation, thus establishing an important link between bedside neurointensive care providers and senior scientific investigators.

K-25 DK02903-01 Bryce CL, PI 7/01/00 - 6/30/04 Co-mentor
NIDDKD
End-stage Liver Disease/Prevalence and Treatment Variations
Major goal of this project: To determine which clinical, demographic, and economic factors affect referral and evaluation patterns for liver transplantation in the treatment of ESLD.

Angus DC, PI 1/01/02 - 12/31/05 PI
ICOS Corporation
Cost-effectiveness of Pafase in the treatment of severe sepsis
Major goal of this project: To conduct a formal cost-effectiveness analysis of Pafase alongside a worldwide Phase III trial assessing the safety and efficacy of Pafase for the treatment of severe sepsis.

Angus DC, PI 9/1/01 - 3/31/03 Principal Investigator
Robert Wood Johnson Foundation
An Epidemiologic Assessment of Use of Intensive Care at End of Life in the US.
Major goal of this project: The primary goal of this study is to provide data that document the extent to which intensive care is provided to Americans at the end of life and understand how the likelihood of receiving intensive care varies as a function of patient and institutional characteristics.

K08 GM63052-01 Clermont G, PI 12/1/02 - 11/30/06 Mentor
NIGMS
Organ system interactions in critically ill trauma victims
Major goal of this project: To completely characterize physiologic variability and construct a mathematical model to describe its association with, and predict organ system interaction during, critical illness.

K08 Barnato AE, PI 3/1/03 – 2/28/07 Mentor
NIGMS
Hospital-level variation in treatment intensity at the end of life
Major goal of this project: To completely describe the variation in hospital-level treatment intensity at the end of life in Pennsylvania; to identify the hospital characteristics associated with this variation; and to determine the effect of this variation on patient survival and inpatient costs.

Completed Research
Nelson J, PI 1/1/01 - 6/30/02 Co-Investigator
Robert Wood Johnson Foundation
End of Life Care for Critically Ill Patients: A National Survey of ICU Directors.
Major goal of this project: The goal of this research was to provide a clearer understanding of current practice and a foundation for changing future practice through specific, targeted interventions to optimize end-of-life care in ICUs in the United States.

Danis M, PI 10/01/01 - 9/30/02 Co-Investigator
NIH Clinical Center
An Epidemiological study of the Use of Critical Care by the Uninsured
Major goal of this project: To determine which clinical, demographic, and economic factors affect the access to critical care by the uninsured in the United States.

GlaxoSmithKline Angus DC, Watson RS, PIs 8/01/01 – 6/30/02 Co-PI
Epidemiology, healthcare resource use, and cost of illness of infection, sepsis, and acute organ dysfunction in a tertiary medical center
Major goal of this project: To determine the epidemiology, healthcare resource use, and cost of infection-related illness, sepsis, and acute organ dysfunction in patients hospitalized at a tertiary, academic medical center.

1 R01 HS09694 01 Roberts MS, PI 1997 - 2001 Co-Investigator
AHRQ
The Optimal Timing of Liver Transplantation
Major goal of this project: To construct a complex, realistic mathematical simulation model of ESLD that is sufficiently detailed to determine the optimal timing of transplantation during the natural course of disease.

1 R25 HS09784 01 Roberts MS, PI 1999 - 2001 Co-Investigator
AHRQ
Program in Clinical Effectiveness/Evaluation Sciences
Major goal of this project: Development of a broadly based, multi-disciplinary health services research training program designed to provide trainees with the skills necessary to meet the rapidly changing demands of health care systems today.

Eli Lilly, Inc. Angus DC, PI 1997 - 2001 PI
Cost-effectiveness of Recombinant Human Activated Protein C (rhAPC) in the treatment of severe sepsis
Major goal of this project: To conduct a formal cost-effectiveness analysis of rhAPC alongside a worldwide Phase III trial.

Ohmeda PPD, Inc. Angus DC, PI 1996 - 1999 PI
Cost-effectiveness Analysis of ECMO and Inhaled NO in the Treatment of Respiratory Distress of the Newborn
Major goal of this project: To estimate the cost-effectiveness of inhaled NO in neonatal hypoxic respiratory failure, separating ECMO from mortality, and use simulation modeling to interpret the clinical and economic implications of the NINOS study for ECMO centers in the US.

Current Research Interest:
He specializes in the epidemiologic, economic and health services research aspects of critical illness and ICU organization and delivery. He has studied the development and application of cost-effectiveness analysis in critical care, the capability and impact of alternative ICU organizational models, traditional and novel ICU risk prediction tools, and the incidence, cost and short- and long-term outcomes of critical illnesses such as sepsis and respiratory failure.He specializes in the epidemiologic, economic and health services research aspects of critical illness and ICU organization and delivery. He has studied the development and application of cost-effectiveness analysis in critical care, the capability and impact of alternative ICU organizational models, traditional and novel ICU risk prediction tools, and the incidence, cost and short- and long-term outcomes of critical illnesses such as sepsis and respiratory failure.